Arsenic up for Review

This amused me. It might amuse you too.

The other night Ed Yong asked on Twitter if anyone could remember mention in a recent blogpost of the fact that salts of arsenic often contain phosphate. I’m guessing he was preparing for his latest #arseniclife post (which — to be serious for a second — is refreshingly candid about his initial treatment of all this arsenic-munching bacteria brouhaha). I thought I had read a note about the phosphate content of arsenates on Rosie Redfield’s blog, but I was mistaken.

Then I wondered about looking up sodium arsenate on the web-site of Sigma-Aldrich, purveyors of fine chemicals to the world’s scientists. I remembered that they often included analyses of the most common contaminants of their products. The page I got to is shown below — unfortunately it doesn’t report on the contaminating salts.

But it does reveal something quite interesting.

SA-arsenate

Sigma-Aldrich have gone a bit, um, Amazon. You will see towards the top that the site invites you to write a review.

This was too much for my imagination. I couldn’t resist:

What a great product! Had been feeling peckish and was delighted to come across this product at Sigma-Aldrich.  Was impressed with the speedy delivery and the quality of the salt. Really great taste with none of the nasty phosphatey residue that you get with cheaper products. Shared it with my buddies at the lake who all agreed it was awesome!

GFAJ-1 (and the gang)

And not only do Sigma-Aldrich want reviews; they are now also suggesting additional purchases based on your selection. At first this seemed a bizarre innovation for a site dedicated to hard-working, focused scientist shoppers. But then I wondered what would be the impact if Sigma-Aldrich were to adopt a random chemical selector to generate these suggestions? Who knows what uncharted zones of chemistry might be discovered!

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29 Responses to Arsenic up for Review

  1. nico says:

    Hahaha I hadn’t noticed that! Wouldn’t it be wonderful if they had a “like” or “share” button though.

  2. Stephen says:

    They could go social media mental if they wanted to!

    (BTW – welcome to the new place, Nicolas).

  3. Ed Yong says:

    This cracked me up. “Customers who bought arsenic may also enjoy phosphorus…”

  4. ricardipus says:

    Sigma-Aldrich is well-known as a vendor of such interesting substances as cocaine hydrochloride, alpha-cobratoxin, pheromones and “dog fear scent training essence” (or words to that effect). Just imagine the review possibilities!

    And, one of my all-time favourite chemical names is “sphingomyelin”. I am sore tempted to write a review: “It’s Sphingomelicious!”

  5. Kevin Z says:

    I am very saddened that there is no image available for the chemicals. I never buy anything off of amazon without seeing all the previews!

  6. Stephen says:

    @Ed – Ha! Thanks – it was you who set me on the trail…

    @ricardipus – {groan} ;-)

  7. Stephen says:

    @Kevin – a very sensible approach. On your behalf I checked whether Amazon stocks Sodium Arsenate.

    They don’t, alas. The query returned the question “Did you mean Sodium Arsenal?” and the third item on the list of suggested alternatives included the book Homeopathy for Horses. Which reminded me of my arsenic overdose earlier this year…

  8. Frank says:

    Stephen –

    I’m interested to know whether the book Homeopathy for horses is very popular in the equine community? You don’t see many horses in our local bookshop, nor even many Houyhnhnms.

    Re. social media and procurement, I was talking to David Kavanagh at Science Online, He is from Scrazzl which aims to bring social media into lab procurement, helping labs to share knowledge and maybe even reagents. It does make some sense. Their website wasn’t very informative last time I looked and I think they are still in fairly early stages.

  9. Stephen says:

    Ah yes – now that you come to mention it, Frank, I remember hearing about Scrazzi at the Science Online conference. I agree it’s a very good idea – it’s just the sort of information that people share at conferences or by email.

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  12. Cath@VWXYNot? says:

    Brilliant, Stephen! This could be the next three-wolf-moon shirt phenomenon!

  13. Stephen says:

    Ha – luckily for me, I have no need of such shirts!

  14. chall says:

    haha – reviewing as an option for buying chemicals. Never seen that (or never thought about it anyway… but I would think I haven’t seen it last time I bought stuff from Sigma…. surely I would’ve noticed).

    As for the As discussion, I’ve tried to stay out of it since part of it seems to focus on other things that the bacterial stuff I find a bit interesting and troubling (doubling time in bacteria growing in non-great media for example)….

  15. Stephen says:

    Why stay out of it if you have genuine concerns? It’s an interesting report but, to my mind, Science was a bit premature in publishing. I’ve had a go at reading the paper but was unconvinced of the strength of the evidence that As was truly incorporated into the DNA backbone. Rosie Redfield’s post raise a lot of tough questions.

    Officially the jury is still out, but if in your abstract you are going to claim:

    “Our data show evidence for arsenate in macromolecules that normally contain phosphate, most notably nucleic acids and proteins. Exchange of one of the major bioelements may have profound evolutionary and geochemical significance.”

    then that evidence needs to be pretty bloody good.

    It is nevertheless a fascinating episode – one to keep an eye on. And you can do that via the Guardian’s story tracker.

  16. Stephen says:

    :-) And welcome to Occam’s Typewriter Anthony.

  17. chall says:

    [I wrote a long comment and then it all went away sinc the CAPTCHA code was wrong. *slight death* i'll be brief this time]

    I didn’t feel like I could contribute too muich more than was already said… I liked Renfield’s comment, although I would have kept the small snide remarks in the middle of it away since it opened up to all these “you are just jealous” etc… but I am usually very specific?sensitve?(can’t find the specific word I’m loooking for… overly scared to be misinterpreted?) in my critique.

    I mainly am surprised that Science would publish that abstract, even if I know that you want to get people to read the article and therefore beef the abstract but… I couldn’t really see the evidence of the backbone in the paper. More annoying for me was that I thought the paper lacked the evolutionary theory on why bacteria would incoorperate As in the backbone if they have small amounts of P (which I guess points to the fact that I think they had more P in the media than to state “devoid of P”, plus that the bacteria ended up having a very long doubling time which would indicate that thy might ustilise As for something…. but most likely in something else than backbone….)

    Thanks for the link to the Tracker! Much appriciated!

  18. chall says:

    …and of course I mean REDFIELD. I knew there was a reason the name felt familiar…..

  19. Stephen says:

    @chall – I agree with you that it is difficult to say anything new on the topic of this paper and share your surprise that it passed muster at Science. I don’t want to dwell on the details (though I think it’s a fascinating episode), but the things that most struck me were:

    1. Was it not strange to find that the DNA samples of bugs grown in Arsenate only contained about 4% As (i.e. 96% phosphorous)?

    2. Why did the editors and reviewers allow the very strong statements about incorporation of As into the bug’s macromolecules when the data in the paper didn’t convincingly nail this point?

    But I digress. I think in fact that this has been a good episode for science because it shows the level of criticism that findings can be subjected to. I hope the climate change deniers and alt. med. supporters are looking on because it should be clear that ‘Science’ is *not * a gigantic conspiracy.

  20. chall says:

    I agree with your 1& 2.

    I think it can be a good thing to show that scientist don’t always agree with eachother – although, for many poeple that makes things even more scary. (Take the vaccination discussion with some MD/PhDs on one side and MD/PhDs on the other side….) But yeah, there is always hope that some people will realize that there is not a conspiracy… hope and all….

  21. Stephen says:

    Not sure what vaccination discussion you are referring to. MMR?

    But I guess when it comes to issues that have a direct impact on the public (not the case with #arseniclife), it is important for scientists to take care about the presentation of what is known. If there is uncertainty, that makes things more difficult, but there is no case for shirking that responsibility (he said, pontifically).

  22. cromercrox says:

    Stephen – this is too chortlesome.

  23. chall says:

    I just found this article in Science (have a little back log on my readings…):
    Science 3 December 2010: Vol. 330 no. 6009 p. 1302 DOI: 10.1126/science.330.6009.1302
    News of the Week Biochemistry “What Poison? Bacterium Uses Arsenic to Build DNA and Other Molecules” by Elizabeth Pennisi

    [not sure on linking to the article, if that's legal or not?]

    As for the vaccination I was actually thinking about last year’s H1N1 and the adjuvant discussion that occurred in some European countries (esp. sweden and other mass-vaccination places).

  24. Stephen says:

    @Henry – :-)

    Pretty sure it’s fine to link, chall — have been doing it for the past couple of years without receiving a writ! — and makes life a lot easier for the reader. The piece you linked to is the commentary on the original paper (available for free for a couple of weeks).

    There was another press conference about the paper this evening – this time with the senior author, Oremland, who was answering questions. Can’t find the link at the moment but there was a pretty good twitter track from @alexwitze a couple of hours ago.

    Afraid I missed the H1N1 adjuvant discussion!

    • chall says:

      Ah… I thought as much with the link!

      I think the adjuvant discussion will come back eventually [read; next time we need large batches of vaccines]. I’ve been trying to write something coherent about the [imho] main issues with the whole thing but have not been able to make it short with clear points…. I’ll probably need to write something over holidays anyway due to work related reviews ;)

  25. steve caplan says:

    Brilliant and funny. Made my day. As a protein trafficking cell biologist, a few years back I got interested in the potential effects of curcumin on endocytic trafficking. We ordered “pure” curcumin, the major curry component, through Sigma. One of my Indian students was aghast that we’d pay $25 for something he buys in bulk for a dollar at the Asian market. In any event, I could easily now envision Sigma suggesting “If you liked curcumin, you may like ‘My Thai’ or ‘Taste of Thailand’ restaurants”. Think of the advertising revenue…

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