Category Archives: Scientific method

In which we’re too close for comfort

It was always going to be a difficult relationship. We knew from the very start that they weren’t very well-suited. After all, they came from such different backgrounds. They were used to such radically different environments. They scarcely even spoke … Continue reading

Posted in Scientific method, The profession of science | 8 Comments

In which the light bulb’s on the other foot

Following on from a discussion about light bulb changing jokes, I was bustling around my lab this morning, getting ready to cryogenically preserve some backups of my new bladder epithelial cell line. I was all set: I’d ordered the Mr … Continue reading

Posted in Scientific method, Silliness, The profession of science | 10 Comments

In which truths are revealed

There are many things I love passionately about science, but one aspect has got to be right up there in the top ten: the transformation of a deep unknown into perfect clarity. I find it amazing that using simple lab … Continue reading

Posted in Scientific method, Scientific thinking, The profession of science | 10 Comments

In which I salute the pioneers

Cell and molecular biology is a bit of a dark art. The way we perform our experiments has been passed down from generation to generation in sacred texts known as “protocols”. Like any recipe used and abused by generations of … Continue reading

Posted in Nostalgia, Scientific method, Scientific thinking, The profession of science | 28 Comments

In which I surface briefly

Greetings, Earthlings: just emerging from my self-imposed laboratory exile for a quick update. I do still exist, and my radio silence can be explained by the fact that I’m in the home stretch of my resubmission. For those of you … Continue reading

Posted in Careers, Scientific method, The profession of science | 21 Comments

In which I scrape by

I’ve been pondering the theoretical maximum number of simultaneous cell biological experiments that one person can do without losing it. I’ve also been testing the theory on a practical basis – on myself. And I can safely report that, by … Continue reading

Posted in Careers, Nostalgia, Scientific method, The profession of science | 38 Comments

In which the truth is out there

Crop circles are so last century. In our lab, HeLa cell circles are all the rage: The tissue culture incubator is currently plagued – not with aliens, but a random vibration or resonance that causes our cells to sporadically seed … Continue reading

Posted in Scientific method, Silliness | 45 Comments

In which I ponder the power of perspective

Whenever you stick your head above the parapet and express a strong opinion in a high-profile venue, it’s almost inevitable that you’ll receive a large number of emails in response. Most of the follow-up I receive tends to be from … Continue reading

Posted in Scientific method, Scientific thinking, The profession of science, Uncategorized, Women in science | 47 Comments

In which I confront a domestic mystery

Some late nights in the lab, that vending machine chocolate bar just can’t fill the snack hole that only a truly grueling experiment can induce. You need something hot, salty and preferably dripping with fat. It’s no surprise, then, that … Continue reading

Posted in Domestic bliss, Nostalgia, Scientific method, Silliness | 52 Comments

In which I tire of the old paradigms

Successful moments in scientific research are famously rare, and people deal with them in various personal ways. Many treat a promising experimental with suspicion bordering on paranoia, refusing to believe what is right before their eyes because an experiment couldn’t … Continue reading

Posted in Scientific method, The profession of science | Tagged , , | 53 Comments