In which I marvel at a serious swag #fail

Who doesn’t love a good conference swag bag? Yes, I know it’s frequently full of useless tat destined to go straight into the hotel bin. But what jolts the adrenalin as you paw through the bulging canvas sack in your jet-lagged haze is the promise of maybe one really, truly cool item: the gadget or gizmo that you’d be happy to swap precious luggage space formerly reserved for cheesy American snacks like Cheetos.

Your future is full of...foam

And so it was at Science Online 2011 last week that I eagerly unwrapped a Magic 8-ball-style fortune teller from Sigma. Finally, something that would give a straight answer to whether I’d be able to stay up until past 10 PM to get drunk with the oceanographers!

As I shook the cube and peered into its viewing window, I was dismayed to see that whatever fluid Sigma had chosen to immerse the magic plastic answer dice was so foamy that it was impossible to make out the words.

Now this is a sad state of affairs. If Sigma, which bills itself as a premiere purveyor of fine chemicals, can’t come up with an appropriate fluid for this purpose, then honestly, who could? (If I could read the reply, the cube might tell me “Reply hazy: try again”.)

Or maybe the entire thing was deliberate on Sigma’s part, an attempt to deliver the ultimate metaphor for scientific inquiry. We might think we’re unraveling the secrets of the universe, but in actual fact, we’re just staring fruitlessly into a window of obscure murk.

Posted in Uncategorized | 19 Comments

In which I tire of the old paradigms

Successful moments in scientific research are famously rare, and people deal with them in various personal ways. Many treat a promising experimental with suspicion bordering on paranoia, refusing to believe what is right before their eyes because an experiment couldn’t possibly have brought good tidings, could it have? Like a young swain disappointed in love one too many times, they harden their hearts against any glimmer of hope or joy.

But when something convincingly good happens to me in the lab, I’m the first one to jump up onto the lab bench and do a victory dance. There are far too many failures in my line of work not to celebrate a success, no matter how short-lived or misguided it may turn out to be. For me, the expression “don’t get your hopes up” is an imperative that goes against human nature. Will I really be less disappointed if something turns out not to be true if I don’t celebrate at the beginning?

No, actually, it will suck either way, so I reckon I might as well enjoy it while it lasts.

Recently, I ended up with a nice result on a minor problem I’ve been chipping away at for a few months now – the icing on the cake. Because I am a particularly sceptical scientist, I’d devised several ways of looking at the same question, had reproduced the experiments a number of times using different conditions and a large number of controls, and had also performed a few experiments to rule out the key formal possibilities. Everything looked as solid as anything ever can in this business. Feeling that irrepressible urge to share the love, I opened up Twitter and told the world that I’ve proved my hypothesis.

In amongst the shower of congratulatory and humorous quips that came back was one sour lemon: I can’t remember who sent it or what the exact wording was, but in essence the tweet chided me for saying I’d proved my hypothesis instead of that I’d disproved my null hypothesis.

Around the same time, I’d had a spectacular failure: a carefully nurtured multiwell plate of cells packed full of interesting questions flew off the microscope onto the floor and was ruined. When I tweeted that I’d had to bin an experiment because it hadn’t worked, someone tweeted (again, I can’t recall who or exactly how it was phrased) that there was no such thing as a failed experiment – all experiments should be designed to give an answer either no matter what the outcome and it was wrong of me to have claimed it had failed. When I explained that the cells had ended up on the floor, this person replied that I had still learned something: as near as I could understand, his stance was that I’d falsified the hypothesis that I could perform an experiment to completion without screwing it up.

Right. Now, I think that Karl Popper had some really interesting and important ideas, but – like Thomas Kuhn and others – I don’t believe that there is one single “scientific method”. And in particular, I don’t think that the vast majority of scientists use falsificationist methodologies in their everyday work, aside from its ghostly remnants in the way we calculate p values for statistical purposes. When was the last time, for example, that you saw the concluding line of an abstract stating, “Here, we disprove the notion that protein X is not involved in pathway Y”? What fascinates me is that I still encounter people who seem to think that science should be done, or conceptualized, this way. It might be a byproduct of education: after all, I clearly recall being taught Popperian methodology in high school biology, and for all I know it’s still being aired in classrooms.

I’d be interested to hear what others think about why this Popperian view remains so compelling to some scientists. Is it a talisman against the growing suspicion that our research methodology is hopelessly messy and subjective, and that we can never really discover the truth? Does it cast some illusion of control, some spell that might separate our personalities from our science? Would it, if rigorously applied, serve to stem our inappropriate hopes and desires for a favored hypothesis to be true?

Posted in Scientific method, The profession of science | Tagged , , | 53 Comments

In which I space out

London is beautiful at Christmas, especially when we get proper winter weather. In this lame-duck week in the run up to the 25th, many people in the metropolis have downed tools and taken off work early for the holidays – even scientists. The streets are full of shoppers, far more relaxed and good-natured than is typical for the usual murderous commuting hordes. Snow swirls down, lights glint, and each famous street competes for the honor of having the most elaborate decorations.

Carnaby Street

A few days ago I was cutting through Soho and stumbled into Carnaby Street, resplendent in retro-chic astronomical décor. Vast glowing heavenly bodies floated overhead as far as the eye could see – planets, stars and the Moon – and snowflakes gently brushed my face as I gazed upwards. I overheard a small toddler say, “Daddy, what’s that big planet called, the one just behind Saturn?” Pretty impressive for a five-year-old.

It is a relief being out of the lab – because of the way the dates worked out this year, I will end up having more than two weeks off, which is the longest holiday I’ve managed in several years. I have been under a lot of stress recently, what with an urgent manuscript needing attention, a long-haul trip to the American Society for Cell Biology meeting in Philadelphia, and the fact that my father remains critically ill in hospital more than 4,000 miles away. I crave, in no particular order, sleep, decent meals and the chance to relax and work on my fourth novel, which has just now started to kick in agreeably. And – unavoidably – I also need to do lot of hard thinking about what might lie beyond the termination of my fellowship twelve months from now, and how best to capitalize on the time I have left. I want to follow my dreams and stay in the lab, but on the other hand I have a mortgage to pay, finances are tight and I’m not getting any younger. In other words, I need to do the sort of honest thinking that the usual working routine does not permit.

But for now, I am practicing avoidance. Christmas is good time for living, like children do, in the moment.

Posted in Careers, Staring into the abyss | 11 Comments

In which I am outwitted by swag

A good scientific meeting will often lead to more questions than it answers. And sure enough, I’ve recently returned from the American Society for Cell Biology with a mystery object that has evaded all powers of comprehension. In the spirit of collaborative, cross-disciplinary research, I thought I’d crowd-source its identification.

One afternoon wandering around the Expo hall, I was selected at random to receive a plastic bag bulging with swag from various exhibitors. Upending it later in my hotel room, I found myself the proud owner of a wide variety of items including four extra-extra-large T-shirts; a pack of post-it notes; a keyring torch; a 4 GB flash drive; an oddly seductive glass paperweight dedicated to the Silver Anniversary of the first publication of Leninger’s Biochemistry; lens paper; a mini-slide holder; and no fewer than 26 bizarrely over-engineered ballpoint pens, some with the girths of bananas.

And this little fellow:

In short, what the hell is it? The device opens and snaps shut like a clam shell, and those white ovoid pads are made of a very firm foam substance.

Whatever it is must be somewhat useful: the mystery item is inscribed with both a US and Chinese patent number, although searches on the internet for their applications drew a blank. In my jet-lagged state, I tried to image what it might be for, but the only thing I could come up with was a device for pressing Drosophila or other small model organisms for your scrapbook, as children press flowers.

Any guesses, serious or otherwise, are welcome!

Posted in Silliness | Tagged , | 37 Comments

In which I question my own sell-by date

The scientific profession is inherently broken.

I’ve blogged in the past about the glut of increasingly desperate post-docs battling it out for a diminishing pool of permanent positions funded by a dwindling pot of research funding. As the culture of our profession stands at the moment, a healthy lab head can churn out 40 trainees over his scientific lifetime – but the only significant source of permanent positions in academia are those same lab head jobs (senior tech jobs being almost non-existent these days, especially permanent ones). So after replacing himself, this leaves 39 scientists in surplus. Industrial and public sector labs will soak up a few, but the rest will have to leave research permanently.

The solution, I’ve argued, is to reduce the number of trainees and to increase the number of permanent, non-lab head positions in the academic scientific career structure: to nurture and cherish the scientists we train, not exploit them for cheap labor to enhance the lab head’s CV and then spit them out when they’ve run their contract-work options into the ground.

Am I bitter? You bet. Is this stance personal? Intimately.

Age discrimination became illegal in the EU in October 2006, but science cleverly gets around this problem by putting restrictions into their fellowship eligibility criteria. At some arbitrary span of time after being awarded a PhD – typically 5-10 years – researchers apparently turn into pumpkins.

Let’s look at my specific example. I received my PhD in June 1996, nearly 15 years ago. Most funding bodies allow you to subtract time out for a career break. Some only allow childbirth or compulsory military service as good excuses, which would rule out my four-year stint in publishing, but for the bodies that don’t care why you left, this will still put me at 11 years when my current fellowship expires. So when the Wellcome Trust awarded me a career re-entry fellowship at year 7, it was with the knowledge that when I emerged at the other end, I would no longer be eligible for any further Wellcome schemes: I’m too past-it for their senior fellowships (10 years) and too junior for their Investigator scheme (which requires an accumulation of corresponding authorships and grants, something that a re-entry fellow can’t realistically expect to obtain when the sponsoring institution doesn’t see us in that junior lab-head role).

At this point it seems clear that I can’t launch straight into a lab head position. It took me quite some time to get back into the swing of things after my career break, and four years was not enough time to build up my CV to effectively compete. What I really need is another fellowship to bridge my way: there seem to be a few options, but I’m already a pumpkin in the eyes of many besides Wellcome: the BBSRC (10 years); the HFSP (10 years), the MRC (6 years, though they allow extensions for “exceptional circumstances”), and so on. In the interests of my non-British readership, I had a look at funding websites in the US and the EU, but was forced to retreat straight away by the veritable wall of jargon. (“F Kiosk”, “SF424 (R&R)” and “PHS 416-9”, anyone? No, me neither.)

I honestly question the validity of an arbitrary sell-by date, which seems so sacrosanct that only “exceptional” circumstances warrant their breach. Is a researcher really qualitatively less attractive at year 11 than at year 10? It shouldn’t matter how old or experienced a research is: she should be weighed on her individual merits. Of course, in a system that churns out a vast glut of young trainees, perhaps the rationale goes something like this: If she didn’t make it in 10 years, she probably never will, so expel her from research and give a young person the chance instead. It reminds me of a scene I saw at Euston Station the other day: a group of tourists coming off the bottom of an escalator and just standing there in bewildered confusion as columns of descending commuters yelled at them to get out of the way so they wouldn’t get knocked over. I was one of the people yelling: can you blame me? If you reach the end of the line, shouldn’t you step aside?

The problem is that everyone is an individual, with his own story to tell. I washed up here at year 11 through a complicated web of cause and effect: yes, a lot of my own career decisions influenced the outcome, but so too did things out of my direct control – a biological model that didn’t pan out, the decision by a post-doctoral supervisor to relocate his lab to a country where I couldn’t follow for personal reasons, a biotech company that went bankrupt. I may be a 40-something post-doc, but this doesn’t mean that I’m not an asset to science, that I don’t deserve a chance to carry on if my CV and track record are good enough.

I propose we call a spade a spade: arbitrary sell-by dates in senior fellowship eligibility criteria constitute age-discrimination, plain and simple. Shouldn’t they be illegal?

Posted in Uncategorized | Tagged , , , | 43 Comments

In which the next train will shortly be arriving on Platform 1

Very soon, Mind The Gap will settle into its new home here at Occam’s Typewriter.

It feels good to going indie with my lovely OT colleagues – in fact, I’m all aflutter. Cue gratuitous London underground shot:

(gratuitous London underground shot censored on account of not wanting to frighten the horses et al. -Ed.)

Posted in Silliness | 14 Comments

In which I come over all SF

Science: it’s not just a profession, but a way of life.

And sometimes it’s hard to switch off the all-pervasive geeky filter through which we view the entire world.

HalfStory.jpg

Of course, the UK press’s habit of weirdly juxtaposing nouns as adjectives in headlines certainly doesn’t help. Although it was always too good to be true, I was strangely disappointed when I grasped the real essence of the story to hand.

FullStory.jpg

Is it Friday yet?

Posted in Uncategorized | 18 Comments

In which I correspond

In my secret heart, I have always longed to live in the Victorian era. Through the rosy-tinted glow of idealized histories (the sort that neglect to mention things like head lice), I’ve imbibed stories of poets corresponding with ornithologists about the precise cadences of particular birds, or of carriage traffic jams in Albemarle Street before public lectures at the Royal Institution, or of the first print run of On The Origin of Species selling out in two days – of a time when science seemed to be a valued, respectable and essential part of all civilized laypeople’s repertoire. But as much as I like the notion of science’s elevation in popular culture, it’s the idea of interdisciplinary correspondence that for me holds the most romanticism.

My second novel, The Honest Look, is officially released on Saturday. During the course of finalizing the copy, I embarked on a few Victorian-style adventures in correspondence of my own, all involving poetry. The scientist protagonist in my novel is a closet poet, and the book is peppered with references. When I received a casual email from one of my contacts at Cold Spring Harbor Laboratory Press in summer that we needed to start working on seeking permission for all of the quoted poetry not yet in the public domain, I had little idea how problematic this might be. We were about six weeks from going to press, and my contact set about the job with cheerful optimism. And soon slammed into a brick wall.

It turns out that many major publishers stipulate that permissions requests must come in writing – through the post – and that turnaround can be several months. When it comes to poetry, there are often scores of publishers peddling various editions, and of course we needed to secure multiple rights (US/Canada, UK, World etc.), which often are held by different publishers. When you send off a letter and no one answers, you start to wonder if anything will ever happen. As my contact reported back that she was having problems with four of my poems, even mooting the idea of possibly swapping them for older ones, I started to get very worried indeed. Some of the quotes were actually integral to the plot, and I didn’t see how I could replace them at such short notice. Coincidentally, that very week, Tony Woodlief wrote a wonderful piece in The Wall Street Journal about how publisher obstructionism – and high cost – had caused him to cut song lyrics from his book. In his words, “Modern copyright practices spur artists to unmoor our work from what has inspired us. Art–along with many artists supposedly protected by these laws–is arguably poorer for it.”

As a scientist, this was uncharted territory. When you need permission to reproduce a graph or figure, you just email a friendly person at the journal in question, and it’s all sorted easily. But scientists are also used to recalcitrant theories and obstacles. Perhaps that is why, ultimately, I enjoyed the challenge of cracking each of the poems in turn:

Quarry 1: Edna St Vincent Millay, Dirge Without Music
Essentiality, on a scale of 1 to 10: Enters the plot at a pivotal moment, contains key messages. Also, provides the title of the book. Although in one moment of panic I actually considered rewriting the scene so that the heroine is shown reading the poem but only paraphrasing from it in her head, seemed a last resort. So, a 9.

My father once had dealings with Edna’s sister Norma, who was looking after Edna’s estate when he sought permission to photograph Edna’s garden for the cover of an edition of her Complete Works. Sadly, Norma had long since passed away herself, so we had no personal leverage. After exhausting all leads with publishers of various editions, my contact at the Press did a bit of intense Googling and came across the Millay Society website, which turned out to hold the copyrights. A few emails later and permission had been granted – free of charge, an unexpectedly generous bonus.

Quarry 2: José Angel Buesa, Poema del Amor Ajeno
Essentiality, on a scale of 1 to 10: Absolutely pivotal to the plot – used as part of a romantic stratagem by one of the characters. So, a 10.

Buesa was an obscure 20th Century Cuban poet, so obscure that the only Wikipedia entry about him is in the Spanish version of the encyclopedia. Hours of research on further Spanish language websites failed to produce even the name of a publisher for various poems reprinted on the internet. Indeed, I was starting to worry that Buesa did not, in fact, actually exist. And then one morning, one of my Google searches threw up the name of a professor at Columbia University, Gustavo Pérez Firmat, in scholarly connection to Buesa. Pérez Firmat replied immediately to my email, telling me that the poem had originally appeared in Oasis, self-published by the poet in 1943. “I have a xerox copy of the book,” he wrote, “and there is no copyright indicated.” His view was that there was no potential liability in quoting from this poem, and that many collections had reprinted it freely over the years. Afterwards, we engaged in a pleasant exchange about the poet and his work, and he even checked over my translation of the poem – which fortunately was deemed sound (aside from one phrase which I’d subtly tweaked for the purposes of the narrative).

Quarry 3: Miroslav Holub, The Moth (translated from the Czech by D. Young and D. Hábová)
Essentiality, on a scale of 1 to 10: Not important for the plot, but featured in a key emotional moment – an absolutely stark and beautiful stanza, as well as humorous. Replaceable, but at a cost. So, a 6.

Having had zero luck with Faber & Faber, the publisher of my edition of The Rampage in which the poem appeared, and with Holub deceased, I decided to stalk the translators for clues. Lo and behold, David Young turned out to be an emeritus professor at my alma mater, Oberlin College. (Any Obies out there will know of its strong bonds of loyalty, and could imagine my sudden optimism.) Young replied to my email straightaway: “Well, shame on Faber and Faber for dragging their feet like that. They don’t even own it! Their book is out of print.” And, as luck would have it, Oberlin College Press itself had published Young’s translation of _The Moth _ in a collection entitled Intensive Care (1996). As the publisher and translator, Young was delighted to give us permission to quote the entire poem, for free. A few quick emails with OCP sealed the deal.

Quarry 4: Margaret Atwood, More and more
Essentiality, on a scale of 1 to 10: Utterly irreplaceable. Is delivered at a romantic climax of the book, and is one of those poems so eerily suited to the situation that one could not imagine anything else in its place. A definite 10.

This was the one poem I was sure I couldn’t crack. The publishers were monolithic imprints, their silence deafening. Unlike university professors and poet societies, one can’t just email someone like Margaret Atwood – although I did try to track down an email address of an agent, with no success. And then, as I sat there, utterly stumped, I suddenly thought: is Margaret Atwood on Twitter?

The answer was yes – with followers approaching 100,000. If I addressed a public tweet to her, asking for her help and intervention, how on earth would she ever see it in such a raging torrent of a timeline? Nevertheless, it was worth a punt. I put a lot of thought into those 140 characters, waited for when she was likely to be awake in Toronto, and then fired it off.

Within minutes, this:

AtwoodNowFollowing.jpg

Followed by a direct message, and then a lively email exchange in which I explained why it would be a crime to replace her poem with some ancient effort from a Dead White Male. Her reply kicked off with: “Just go for it. I will deal with the flak.” She explained the complicated copyright situation, sympathized with the impossibility of permissions quagmires in general, and then told me just to have my publisher her send a cheque for an appropriate amount and she’d divvy it up to the right places personally. A few further emails with her personal assistant secured the transaction.

The novel involved other bits of correspondence, too: the native Spanish and Dutch speakers who helped me select phrases to add color to the text – I speak both languages, but not very proficiently – and who helped persuade me to drop the accent mark from one of the character’s names, because that’s what long-term ex-pats tend to do. Then there were the scientists I consulted on the molecular biology of Alzheimer’s disease. And of course, the many dozen volunteers who read through various drafts, skewering me with heavy criticism and tough love. (My favorite line of marginalia, from Professor Clare Isacke, is still “Ludicrous! That is to say, utter tosh.”)

It’s been a great adventure, and a deeply satisfying meeting of minds. And all of it was greatly facilitated by methods of communication beyond the Victorians’ wildest dreams.

The Honest Look (Cold Spring Harbor Laboratory Press) is now available:
Direct from publisher
Amazon.co.uk
Amazon.com
Amazon.de

Posted in Uncategorized | 23 Comments

In which I contemplate the ranks of the invisible

The word ‘feminist’ has ugly connotations, so much so that I often hesitate before pointing out gender inequities. Does it do any good to state the obvious, given that it is unlikely to rectify injustice, and indeed risks riling up, or boring, those who are just not bothered by that sort of thing?

For some reason, my system refuses to become sensitized. It rankles every single time. Every time I turn the pages of a newspaper and see that the majority of serious stories are about men, maneuvering for positions of power in government, finance, business and sport. Every time I read the statistics about how women still almost universally receive lower pay than their male counterparts for doing the same job. Every time I switch on a BBC quiz or comedy show and see that the three people arrayed on either side of the host are all, or nearly all, men.

It gets worse when we venture into science. Let’s leave aside the obvious figures about the scarcity of female scientists above the post-doctoral level. I’d like to focus on the public face of science. It bothers me every time a science documentary employs all or mostly male scientists as expert talking heads. Every time ‘the best’ science bloggers are published, and most of them are male. Every time I run my eye down a long-list of science book prize candidates and see one women, or page through a science magazine and see that few of the pundits are women, or listen to a science podcast and hear only men’s voices, or watch science programs on TV and see mostly male presenters.

What rankles me most of all are cases when, instead of getting a few female scientists to join with their male counterparts on the quiz show, panel or magazine, the producers prefer to ask male celebrities who have become known for being “science-y” even though, actually, they might have only done a science degree long ago, or have written a book featuring a bit of science – or have just confessed to being a little bit “geeky” because that’s rather trendy at the moment. The message is clear – it doesn’t matter who fills those slots, as long as they’re well-known (and, possibly, male, though that’s not as clear, as I’ll discuss in a moment).

I think we can agree that in the world of popular science, women are largely invisible. I have, of course, heard the usual arguments: there really aren’t any well-known female scientists. Well, except X, Y and Z, who get trotted out again and again as if they are the only interesting, talented and articulate women in the country. Where is the female Stephen Hawking, the female David Attenborough, the female Richard Dawkins, Steve Jones, Martin Rees, Brian Cox? Why is nearly every up-and-coming television science presenter (who doesn’t even have to be a practicing scientist) a man? Why does no one seem to care about the opinions of female scientists, or female non-scientists with past science credentials, or think that audiences wouldn’t want to listen to them?

I suspect the answer is not deliberate sexism. I suspect that it is all down to the cult of celebrity, and that men are just better at becoming famous in traditionally male-dominated fields like science. Given a choice between filling a seat with an unknown female scientist or a non-scientist rock star, anyone worried about audience numbers is always going to go for the celeb. You could also argue that science needs all the glamor it can get, so it would be madness not to snag a famous comedian if you can swing it, to make your production more palatable to the masses. I respect these reasons, but I don’t think it has to be this way.

And this is why: there is no such thing as a celebrity who did not take his first step out of obscurity. Physicist Brian Cox may right now be the most sought-after talking scientist head in Britain, but there must have been a time when someone took a punt and gave their platform to an unknown quantity. I assume that, for whatever reason, unknown male scientists are more likely to push themselves into the spotlight than their female counterparts – so if an insightful or broad-minded producer or editor wants to discover the next female Brian Cox, he or she needs to give them a hand up. If you don’t put any thought into the line-up of your program, you’ll just end up with the usual bunch of men.

The non-scientific media can occasionally be good at this. I’m thinking of something like BBC News Night Review, which often features obscure young female pundits on the sofa next to their established regulars. Someone, in this case, is obviously putting some effort into researching, approaching and fostering new talent. Alternatively, established male scientist pundits might occasionally recommend articulate and outgoing female colleagues to their producer contacts. All it takes is a little thought, and a little extra work. I know scores of fabulously funny and insightful women scientists and science-related folk who could genuinely engage with a broader audience, whether in print or broadcasting: why do we seldom hear from these people?

I guess the more important question is this: is it actually a problem that our ambassadors for science are all or mostly men, as long as they are talented and the message gets across? Some people don’t think so: for example in a recent Twitter exchange about the absence of women on the inaugural episode of the podcast Strange Quarks, although Martin Robbins expressed regret, Alice Bell tweeted “…I’m not too fussed abt numbers tbh, it’s quality + context around these things that matter”, although she also allowed “I think it’s worth noting big gap like that b/c often people don’t think to ask.”

But I’m afraid it is problem for me, because I do know these wonderful but obscure female colleagues who would love the chance to reach a broader audience, and the glaring injustice overshadows everything else. It might also be a problem for young women interested in science, who have little more than starving models, footballers’ wives and singers in rehab for role models and who see or hear little recognizable as themselves in the science-related media.

I don’t know. Is noticing the gap and appreciating what may be the perfectly valid reasons behind it, as Alice suggests, enough, or do we actually want to change things? It is important to stress that I am not advocating getting mediocre women involved for the sake of looking balanced: that’s anathema to me. I am stressing that I would like to see more excellent women, women who are as good or better than the men that routinely appear, involved in the science media world. They exist, and many of them are willing. If they don’t put themselves forward into a world where they can see little or nothing like themselves, can you blame them? Would getting more women involved break the vicious circle of no women being routinely seen leading to no women worthy of being asked, because nobody knows who they are, or even notices their absence?

I think it just might. Why don’t we do the experiment?

Posted in Uncategorized | 75 Comments

In which we experience a visitation

As a force of nature, you can’t get much more powerful than a first-year rotating graduate student: one part youthful stamina and nine parts unrelenting enthusiasm. This year in our institute I took part in a new experiment for dealing with the annual crop of incoming PhD candidates. Previously, before embarking on their first placement, they would have been subjected to a month of lectures and a series of practical demonstrations. These demos used to take place in the unused half of our laboratory, supervised by one of the more dynamic lab heads: brand-new boxes of gleaming Gilsons and tips and a series of out-of-the-box experiments designed to flex virgin thumb muscles and get feet wet. Although it was always heart-warming to see the troupe of white-coated fledglings following their instructor around the lab, I often wondered how useful – or interesting – these exercises actually were.

This year, though, someone came up with the idea of putting the students into teams of two, assigning them a gene and asking them to find out as much as possible about it, both through literature searches and direct experimentation, in a three-week period. Their first task would be working out who in the building would be most appropriate to give them a hand, based on the identity of the gene, and then identifying which people would be the best expert advisors for any given task. Of course the bulk of supervision would fall on the person whose pet gene had been assigned to the pair, but the idea was to spread the load of supervision across the whole building while giving the students the skills they needed, including the fine art of schmoozing and scrounging – which in some ways might be just as important as ace pipetting for long-term success.

One of the genes from my screen was selected as student bait (with my blessing, of course), and soon a twin whirlwind had blasted into our lab. The great thing about having students around, even for a short time, is that it forces you to dust off that important task that’s been languishing because you simply haven’t had time to deal with it. You might think you’re busy, but when two pairs of puppy-dog eyes are staring at you imploringly, you really have no choice but to make time to help. Every time you agree to supervise someone, you run the risk of putting in a lot of effort for very little tangible output for your own project, so you always hope that it will be worth your while.

Dear reader, the students exceeded my wildest dreams. In only a fortnight, they’d made two DNA constructs, performed a key rescue experiment in cells and made a preliminary foray into inspecting the effects of gene knockdown on RNA splicing. A few nights they even worked til midnight, and I had to physically restrain one of them from doing more experiments the evening before their big report was due. They were so autonomous near the end that I often had to chase them to find out what results they’d actually achieved. And they weren’t half coy about their accumulating data: one afternoon I came back to my desk to find this tantalizing little heart-breaker:

RTPCR2.jpg

The postdoc is always the last to know.

Posted in Uncategorized | 10 Comments