On philosophy

At this point Festus interrupted Paul’s defense. “You are out of your mind, Paul!” he shouted. “Your great learning is driving you insane.”

Acts 26:24, NIV

Theodore Zeldin is a philosopher. As far as I can work out, this means he gets paid to say things that nobody in their right mind would even think. I say this because a week ago I read in that epitome of news reportage, the Evening Standard (now free from all good Tube stations), that Zeldin threw a dinner party on Saturday where there was no food, but rather a list of supposedly conversation-provoking questions.

The plan was to get up to 200 people, paired with random strangers, to talk:

People in this world of superficial communication find themselves isolated and lonely and have difficulty in talking about personal things that really matter to them.

Well, all right. But this is actually a thinly-veiled attack on two mainstays of conversation and human interaction today: Twitter and Facebook: an antidote to the superficial conversations of Facebook and Twitter, to encourage people to open up to each other in more meaningful ways.

He seems amazed or surprised that at one event he organized, “they started at 7pm and some people were still going at two the following morning.” Yeah. Whatever. I used to talk through the night when I was at college, too.

Zeldin apparently has never been on Twitter or Facebook. The ability to have a non-superficial conversation does not depend on the medium, as any letter writer will tell you. More to the point, Twitter and Facebook facilitate human interaction: I have met far more interesting people through these media than I would have otherwise (the last time being a couple of Tuesdays ago at a #UKScitweetup event I organized). Some of my best friends, the very people I would open up to and discuss the secrets of the universe, I have met on Twitter or other parts of the internet. The failure to have ‘meaningful’ conversations is the fault of the people involved; indeed, a failure of vision in realizing what is possible.

If this is the state of philosophy in the 21st century, then philosophers are in great danger of becoming irrelevant. It may already be too late.

Posted in Internet, People, Rants | Tagged | 51 Comments

On boggling

You know, I really hate to send traffic over to Pharyngula, because it’s rather tiresome and whatnot, but Henry Gee just alerted me to something quite extraordinary.

There’s a lovely, well-crafted Futures this week (sorry, subscription required) by Shelly Li. And a response on Pharyngula, full of hate, bile and spittle

…aimed at Henry.

The piece is about a dystopian future in which people of faith are identified by certain brain signals (when they pray) and subsequently ‘cured’ by forced surgery. You can take the story several ways, seeing metaphors for forced sterilization, eugenics; just about anything.

But the PZMyerites, the most blinkered load of reactionary anti-intellectuals I’ve ever had the misfortune to come across, see it as a direct attack on atheism. Even if it that was Li’s target, I fail to see a problem (why should atheists have a privileged position above satire and ridicule anyway? It’s not as if every other classification doesn’t get its fair share of abuse), and, as Henry writes on Facebook,

I think Li is a super author… And what PZ and his crew don’t quite grasp is that the views of characters in stories needn’t bear any relationship to those of the author, let alone the editor, or anyone else.

It strikes me that people who get upset at such things, and turn that upset into personal and misguided attacks, were possibly dropped on their heads as children (and need to smoke something, seriously dudes). Or maybe it’s because saying outrageous things is bound to attract attention, and giving the business model, attention = $$$.

Sound familiar?

Posted in The stupid, it burns | Tagged | 35 Comments

On being dull

In case you missed it, Web of Stories has just uploaded a load of videos of one of the most notorious of all Nobel Prize winners, Jim Watson.

In this video (there’s also a transcript), Watson talks about The Double Helix and how he wanted it to be a classic; which he tried to achieve by saying things like ‘scientists are dull.’

You know, you can’t be filled with doubts when you might be eaten by a crocodile the next day.

Speak for yourself, Jimbo.

There’s an amusing bit about Cambridge being beautiful but hung up on honoring people who are still alive, and how Oxford just gets on with it:

I’m much more at ease in Oxford which doesn’t identify me, doesn’t have to honor me and, trouble is, Oxford’s not quite as beautiful.

Go take a look. Fascinating stuff.

Posted in People | 2 Comments

On impact factors

They’re crap, aren’t they? Seriously.

Jenny writes that scientists need metrics that reward effort as well as luck. While that’s true, we also need metrics that aren’t capricious and as susceptible to gaming. At the day job, Bob Grant (no relation) tells us that a single paper in that well-known publication Acta Crystallographica – Section A gave it the second highest impact factor in the “science” category.

I signed up at ResearcherID yesterday, for gits and shiggles. I was stunned to find that five of my papers have an average of nearly 100 citations, mostly due to some antibody mapping work I did in my thesis (and my name is incorrect on the author list, natch). The others (and in my opinion some are much ‘better’ work) are barely cited at all.

And PLoS ONE, dear old PLoS ONE, excited because it has an Impact Factor of more than four. Ridiculous.

In what sane universe does any of that make sense? Oh, the Thomson Reuters one, that’s right. Even Eugene Garfield warns against mis-using the impact factor, but nobody appears to be paying attention.

“You should never use the journal impact factor to evaluate research performance for an article or for an individual — that is a mortal sin.”

Nature

But, as I was forcibly reminded at a conference in Charleston last year, people have been whinging about the Impact Factor for thirty years. And still we’re stuck with it. Still people are using it. Whaddya gonna do about it?

Back at the day job I’m writing a paper on alternatives–well, one in particular. And I know, I know that isn’t the answer. I’m not sure what the answer is. I just know that the current system, as we’re all saying, is unfair; and it’ll take a concerted effort to change things.

If you want to change things, of course. Maybe you’re happy with the status quo. Maybe all this talk is so much hot air and we should simply deal with it. What do you think?

Posted in Literature, Rants | Tagged | 23 Comments

On the unkindest cut of all

We’ve been talking about the deficit, budget cuts, what this means for science and whether we should fight our corner and all sorts of stuff in the last couple of months or so.

So, through the wonders of Facebook last Friday night I discovered that whole research groups are being cut, preemptively, at the Natural History Museum. Get the full story at the day job. (hey! Reportage!)

Posted in Funding | 25 Comments

On advertising

Now, we know that advertisers lie to us. It’s right there in the DNA. But here’s a little competition for you.

Ad in Nature

This is (part of) an advert in this week’s Nature. Can you tell what made me so cross about it?

Posted in Rants, The stupid, it burns | 18 Comments

On coupling

No, not that sort of coupling.

I was writing up today’s Faculty Dailies, catching up on (yet) another paper about how ribosomes control the rate of transcription.

As has been known for decades, bacterial transcription and translation are tightly coupled. What’s interesting about the recent work is that the presence/processivity of the ribosome appears to feedback on the rate of transcription by stopping the RNA polymerase from going backwards. (I can’t help but think there’s also a link between this phenomenon and the observation that rare codons slow translation, but that’s something else to worry about.)

Now, when I was working on nuclear trafficking I managed to get our lab’s website into the first page of Google hits for that term (about third, I think). That’s irrelevant: what is relevant is that I left the field nearly five years ago, and at that time we all assumed that, just as in bacteria, translation and transcription were tightly coupled in eukaryotes. How can this be, seeing as they’re in separate compartments? Well, we figured that the messenger RNA was being exported through nuclear pores while the arse-end was still being transcribed. All the RNA-binding proteins seemed to interact with enough of each other that we could happily hypothesize a continuum from chromatin through RNA polymerase through the splicing machinery to the nuclear pore.

Besides, we couldn’t figure out what made mRNA go in one direction through the pore (i.e., out)–although we were pretty certain that it was ribosomes clamping down on the mRNA as it poked out of the nuclear pore, stopping it going back in, and equilibrium dynamics doing the rest (in much the same way this paper postulates that preventing back-tracking is how ribosomes control RNA polymerase)–so this made intuitive sense and seemed to answer a lot of awkward questions. The actual mechanics were simply a matter of time, we figured.

So, coming back to this morning, I was a little surprised to find the sentence

In contrast to bacteria, transcription and translation in eukaryotes take place in different cellular compartments and are not coupled

in a “Research Highlight”:http://www.nature.com/nrg/journal/v11/n6/full/nrg2803.html in Nature Reviews Genetics.

Um, has the field done a complete volte-face while I was noodling away at zinc fingers and websites? Were we wildly ahead of our time, or just completely wrong? What is the latest thinking on this? Anybody got a Stryer?

Posted in Literature, Science | 2 Comments

On #FAIL

What century are we living in, again?

Fail.jpg

Could be worse, I guess. They might have been running MT4.

Posted in Rants, Science-less Sunday | 15 Comments