Cell has a featured preview today of a paper titled “STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1”[1], with STIM1 standing for stromal interaction molecule 1.
The title of the preview?
“A STIMulus Package Puts Orai Calcium Channels to Work”
Excellent.
1 Sorry, Henry, but apparently “CAD activated Ca2+ entry without depleting intracellular stores” (emphasis mine).
shame. I guess it had to happen someday.
I’ve just spotted another one:
A Radical Bailout Strategy for Cancer Stem Cells
Bailout? What interest rates were they charging?
Too much interest, not enough equity.
or you mean, too much interest, no actual data? I talk to people daily who swear up and down that they exist, and also with the groups who swear up and down that cancer stem cells don’t exist.
I’m arguing with a group right now that is trying to convince me that since their cancer “cell line” expresses a protein that has been found in populations that are stem cells in OTHER tissues must mean it is a cancer stem cell in their CELL LINE. Let’s be honest, the mere expression of a marker with no appreciative actual stem cell function doesn’t CAUSE it to be a cancer stem cell. Cause = effect? Nope! Somehow, the idea of a “correlation” gets lost amongst the people I talk to…argh.
Also, I disagree with the scientists believe that cell lines can be used in place of real tumor/tissue even though the correlation was shown in tissue, and clearly demonstrated by others not to work in cell lines. But they keep working with cell lines because they don’t have access to the “real stuff”.
/rant
Well, there’s some evidence… the jury is still out on its interpretation though. Have your group heard of functional assays at all?
And, just because I’m in flickr,
wonder if OJ’s sells these yet? 3 hours and 9 minutes…
No, functional assays, ie supporting data, seems to escape their thoughts.
1 hour 10 minutes until Beer O’Clock!
Yes, if my behemoth of a Word file has converted to PDF by then…
19.8/20.3 MB. C’MON! I need to merge this PDF with 2 others and then upload it before I can submit this grant. It’s taken about 13 minutes to get this far…
AARRGGHH WHY MUST YOU TORTURE ME??!! THIS IS F#*&ING PAINFUL!!!
(sorry)
OK, it’s done. Sorry about the shouting. I’ll keep that comment up there, I’m sure it’ll amuse someone…
Have a great weekend – sounds like you need it,,,!
Erm, thanks, and yes I do!
I was a wee bit hyper for the first hour in the pub,
Cath and Kyrsten go to the pub
but then I calmed down. Getting ready for a ski trip now…
wee bit hyper? I thought you’d go supersonic when you first arrived. I have to say that my “iced tea” helped muchly for my week too 🙂
Gah. Just reading this (linked from a more recent blogpost of yours).
This probably won’t make you feel better, but at least you’ll see that I’m sympathetic.
Yikes! That’s one of my frequent nightmares. I am not as diligent as I could be about creating multiple versions etc., although our servers get backed up every day and I’ve used the archives to retrieve lost documents before. I’m glad you got it all sorted out.
In this case the file eventually uploaded, but it was a close call deadline-wise.