Hockey Pool, Week 12

The last update of 2010!

Well, I originally thought I was having a cracking week… but then I looked at the standings this morning!

Week 12

This week’s top point setters were Ricardipus and Lavaland, who managed 42 and 40 points, respectively. Ricardipus won the right to lord it over the rest of us as he leaped from 6th place to 3rd, while Lavaland is our star at the top, with clear space opening up between her and the rest of us. (Chall – Yule not be happy to see that, but there’s snow way you should be giving up hope just yet!) My 30 points look rather poultry in comparison, although I did slightly close the gap between me and Bob, whose position in the middle of the pack looks nice and stable.

At the other end of the table Thomas clearly made some wise picks as he made up ten points on GertyZ, who unfortunately seemed to stuff her team with turkeys this week. ScientistMother didn’t fare much better, and may need to put myrrh thought into today’s picks.

So – who wants the honour of hosting the first update of 2011?

Posted in English language, hockey pool, silliness | 10 Comments

SURPRISE!!!

The Oatmeal had a wonderful comic this week called “How Different Age Groups Celebrate Christmas”. I can certainly relate to the “children” section – my parents always made a huge deal out of Christmas, and the Christmas Eve anticipation was almost unbearable at times. I remember my sister and I falling asleep on the sofa on Christmas Day once after lying awake and whispering to each other in the dark literally all night in excitement (we always shared a room on Christmas Eve, a tradition we continued well into our 20s! Although we stopped staying awake all night when we hit our teens).

Surprises were always a HUGE part of Christmas. We’d write letters to Santa, outlining our requests, but we’d usually get maybe one present from the list, and the rest would be my parents’ choices. (BTW, our best gifts EVAH were a Lego train set, and Slinkies. We got the latter the same year as our first ever computer, an Atari way back in 1986, and it took our parents hours to set it up on Christmas Day; by the time they succeeded we’d given up watching them, broken open the Slinkies, and told our parents we were having far too much fun on the stairs to come and look at the computer). My parents always bought each other surprise gifts, too – I remember one year when they bought each other three identical presents!

But one year, I ruined the surprise.

We were living in Germany, so I must have been very little – we left when I was four – and I don’t remember the story. But my Mum certainly does, and likes to remind me of it whenever she gets the chance…

She’d done all her shopping with us kids in tow – an exhausting experience, especially since her German wasn’t fantastic – and had finally managed to find everything she wanted. Feeling happy, she came into the living room – where she found me telling my Dad exactly what she’d bought him, while he tried to make me stop talking. My mum immediately joined in his shushing efforts, and they succeeded with one item left unstated – a fancy new leather-bound address book.

The next day was Christmas Eve. My Dad was looking for his cousin’s phone number in his old, decrepit address book, and it fell apart in his hands. He announced that since he had the day off, he was going into town to buy a new address book so he could write the numbers of all the relatives we needed to call on Christmas Day into the new one.

“Don’t bother”, said my Mum with a sigh.

(He still has the address book she bought him that year, by the way. Germans know how to make long-lasting address books, apparently).

Back to the Oatmeal cartoon

I found the panel depicting 30-somethings without kids particularly amusing. Mr E Man and I seem to alternate between genuine-surprise-present years and tell-me-what-you-want-and-I’ll-buy-it years, but we do always at least wrap the presents, and we also do stockings stuffed with surprise gifts.

This year has turned into a tell-me-what-you-want-and-I’ll-buy-it year. I’ve bought Mr E Man a SlingBox doohickey that you can hook up to your hard drive DVD recorder and access remotely, so you can set up and watch recordings from a laptop or cell phone (why does he want this? Well, we’re going to be in England during the NHL play-offs next year. So if you’re one of the people we’re planning to meet in May, please don’t be offended if he’s watching the Canucks* on his phone in the pub).

I asked for a bookcase. My books are currently stuffed into an overflowing dresser, leaving no room for the nice glasses we got as wedding presents and which are, in turn, taking up kitchen cupboard space we could really use for other things. It’s really hard to locate and extract specific books from this disaster zone, and besides, I love bookcases (they just weren’t a priority when we moved into our unfurnished house bringing only a coffee table and a TV stand with us from our tiny apartment).

I also wanted an iPhone 4, which was supposed to be my birthday present (my birthday is in February and no, I didn’t get anything else from him), but I knew better than to ask for one; we’d been to the Rogers and Apple stores approximately every second weekend since the phone launched in August, and they’d never had any. Mr E Man had also tried to get one every single day for a week when he was off work with his injured hand; no joy. I assumed there was no point even looking in December.

Anyway… Mr E Man has been running around like a headless chicken all week, bless him, getting everything ready for the Waifs and Strays Christmas Day Dinner we’re hosting for our friends from Ontario, New Brunswick, and Turkey who can’t make it home to their families. (I’ve been working all week and we’ve been either out of town or busy for the last three weekends). So I assumed he hadn’t had any time for Christmas shopping, and told him that as long as I had a stocking on Christmas Day I’d be as happy as a kitty in a box of tinsel, and that we could get the bookcase in January and the iPhone 4, well, probably never (or maybe the week before the iPhone 5 comes out).

So I was at work on Wednesday, listening to podcasts and trying not to be too resentful of all my friends who were already on vacation and having all kinds of good times without me, and suddenly noticed that my phone had no reception. No big whoop – it happens – but when the problem persisted I grew more and more puzzled. When I got to our friends’ house that evening for another friend’s birthday pinata and dinner, I asked everyone else who’s on Rogers to check their reception, and all their phones were working normally. While the birthday boy (who works for Telus) and the host (who runs a computer support company) were trying to fix my phone, Mr E Man walked over and put a box in my hand, nicely wrapped, and of a familiar shape and size.

“Happy Birthday and Christmas, babe”, he said.

After I went “ooooooOOOOOOooooooh!!!!!!”, I asked if this was the reason my phone wasn’t working. He sheepishly said that he’d asked the guy at the Fido store (yes, he had to switch me over from Rogers to get me a phone) not to activate it until we called to request it, but that he’d forgotten to remind the guy and my number had been switched over to the new phone. “It was supposed to be a surprise…” he said.

Ah well. These things happen. And I looooove my new phone.

Last night, I got home from work while Mr E Man was still out; he’d bought a frozen goose and had apparently decided that the best way to defrost it was to take it to the pub to meet his friends. So I snuck into the back room (that we never use unless we have guests) to retrieve the hidden gifts I needed to wrap and put in Mr E Man’s stocking…

…and found a bookcase.

It’s a really, really great bookcase. I love it. I’ll post a photo once I’ve put all my books in it. And I knew that Mr E Man had put it in the only room in the house where he thought I wouldn’t see it before Christmas Day.

Touched by his thoughtfulness (and excellent taste), I decided to pretend I’d never been in that room and hadn’t seen the bookcase…

…but he came through the front door with the goose just as I was leaving the room.

Well, if you didn’t laugh you’d only cry, as my sister likes to say.

I wonder if I’ll still be hearing about the phone and the bookcase 30 years later, like I do with the address book?

Anyway:

HAPPY CHRISTMAS!!!!!!!!**

to all my wonderful readers. I hope you have a lovely day with family and friends (and get some lovely presents, whether they’re a surprise or not).

(Oh, and DON’T FORGET TO VOTE!)

————————-

*hopefully. I did warn him that buying the SlingBox could well jinx us.

**or Solstice / Winterval / Festivus / other celebration of your choice!

Posted in current affairs, family, food glorious food, personal, shopping, silliness, sport, technology | 12 Comments

2010 Travel Meme

As seen at Silver Fox’s excellent blog, here is a summary of all my 2010 trips (loosely defined!)

All my travel was local, but wow, what an awesome year…

January

We spent Christmas and New Year at my sister-in-law’s up near the Sun Peaks ski resort, in the interior of British Columbia. Here’s Mr E Man on a snowmobile:

Sun Peaks, January 2010

February

Why travel anywhere when the whole world came to Vancouver for the Olympics?! Here we are celebrating my birthday at the Canada-Norway men’s hockey game:

Canada Hockey Place, aka GM Place, aka Rogers Arena, February 2010

My good friend Mermaid did travel during the Olympics – all the way to Whistler, to watch the ski jumping, luge, and other events. She very kindly contributed a guest post to my blog, which I say counts for this meme:

Mermaid in Whistler, February 2010

March

A group of us from work went down to San Diego to meet our collaborators, a few days after the Canada-USA gold medal hockey game. We may have mentioned it a few times per hour.

A couple of weeks later it was my turn to head to Whistler, to watch some Paralympic downhill skiing:

Winter sports are dangerous! Whistler, March 2010

April

I don’t seem to have gone anywhere in April. Oh well. I’m sure I had a good time anyway.

May

We took my parents on a road trip to see Mr E Man’s sister and her family in Kamloops, on to Whistler (where we were lucky enough to spend an hour watching a family of bears hanging out in the lane behind our condo), and then to visit Mr E Man’s Mum on the Sunshine Coast:

Whistler (again), May 2010

June

I went to Seattle.

On my bicycle, mofos!

250 km. Too painful for photos, apparently, although there are some stills in the video at the link above.

July

We started our five day kayak trip in Desolation Sound. It was the best trip yet…

Desolation Sound, July 2010

August

…and therefore worthy of two photos (the trip ended in August, so this is all good):

Curme Islands, Desolation Sound, August 2010

A couple of weeks later we went to a music festival in Cumberland, over on Vancouver Island:

Big Time Out, Cumberland, August 2010

and spent as much time as we could escaping the heat by drinking cold beers in the nearby river:

Somewhere near Cumberland, August 2010

September

Back to the Sunshine Coast, for a family wedding (SO. MUCH. FUN!)

Halfmoon Bay, September 2010

October

Back to San Diego, for another meeting with the same collaborators.

November

Um. Does White Rock count? (Just barely, I’d say – it’s very close to home, but we did stay overnight in a B&B, for reasons relating to predicted and actual drunkenness):

White Rock, November 2010

I also had a staycation, which was fantastic.

Vancouver, November 2010

December

Back up to the Sunshine Coast, for a big happy chaotic family pre-Christmas party, complete with a multitude of nephews, dogs, and remote control helicopters.

No other travel to report for December… although my blog moved. Does that count?

…………..

It really was an outstandingly excellent year. It’s going to be hard to top it… but I’m gonna try! Mr E Man and I are planning a trip to the UK in May, and I hope to meet up with my Occam’s Typewriter co-consipirators, and assorted other blog buddies, which will also be superawesomesauce.

Consider yourself tagged for this meme if you’ve blogged about a trip you took during 2010!

Posted in 2010 Olympics, blog buddies, camping, Canada, cycling, drunkenness, family, kayaking, meme, meta, music, personal, photos, silliness, snow, sport, travel, Vancouver | 8 Comments

Dendrology

My institute seems to be taking a “Less is definitely not more” approach to Christmas decorations. Oh well, at least there’s no mistletoe in the elevators this year…

…yet. The silly season approacheth.

The lobby of my building, this morning. I swear there were only three trees when I left last night...

The sight of all those trees reminded me of an old flatmate of mine, who is also one of my best friends. We were randomly assigned to the same University-owned flat when we moved to Glasgow to start our PhDs; this kind of system is a real crapshoot, but luckily for us we got on like a house on fire – almost literally, at one of our infamous parties – and had three other randomly-assigned flatmates who were also lovely.

We moved in at the beginning of October 1998, and in December we decided to host a big party before everyone scattered around the world to join their families for Christmas. And, of course, we had to decorate.

My best friend (on the very left of the photo below – yes, that’s a colander on her head. Why? She didn’t have a hat) and I were in charge of decorating the flat. We bought a small fake Christmas tree, some lights, and some shiny red and gold ceiling decorations. The place looked lovely, the party was a raging success (this wasn’t the time we almost started a fire), we met our lovely local police officers for the first time*, and we all went home happy for family Christmases in England, Wales, Ireland, France and Malaysia.

Christmas 1998. Please note the normal levels of decoration.

The problem came when we all dragged ourselves back to Scotland in the New Year. I started to take the decorations down – but my best friend stopped me.

“It’s so depressing that Christmas is over, can’t we keep the tree and decorations up a bit longer? At least until the days start getting longer again and it’s not so dark all the time? It’ll look so boring without them…”

She begged and pleaded and the rest of us relented, despite some French mutterings about the proper way of doing things, superstition, and bad luck.

The tree and decorations were still up when we moved out in September 1999.

My best friend, another flatmate and I had rented a privately owned flat nearby, and moved all our stuff over. The Christmas decorations were the last things to come down…

…and the first things to go up in the new place.

My friend did it while my other flatmate and I were out, and looked oh so proud of herself when we came home that we decided to let her keep the decorations up. (She also persuaded us to get some goldfish. She’s a very persuasive person).

The next problem came as Christmas 1999 approached. My friend wanted to buy a second tree.

Why?

“We’ve got used to the one tree and the decorations being there, so it’s not special any more. We need to get another tree to make it special for Christmas”.

So, two trees and more lights and decorations. Christmas 1999 took place in a veritable Santa’s grotto, a festive winter wonderland.

January 2000:

“It’s so depressing that Christmas is over, can’t we keep the trees and decorations up a bit longer? At least until the days start getting longer again and it’s not so dark all the time? It’ll look so boring without them…”

December 2000:

“We’ve got used to the two trees and the decorations being there, so it’s not special any more. We need to get another tree to make it special for Christmas”.

January 2001:

“It’s so depressing that Christmas is over, can’t we keep the trees and decorations up a bit longer? At least until the days start getting longer again and it’s not so dark all the time? It’ll look so boring without them…”

December 2001:

“We’ve got used to the three trees and the decorations being there, so it’s not special any more. We need to get another tree to make it special for Christmas”.

Yes, you’ve read this right – we ended up with four Christmas trees.

FOUR!

Year-round!

In a tiny student flat!

And a shedload of lights and decorations!

(And, of course, each tree had to be bigger than the next. The first one was maybe a couple of feet tall, the fourth was a good six feet. The best part was when the three of us were in Woolworth’s to buy the final tree, the two normal flatmates lecturing our tree-hoarding friend about how this was the last time we would let her get another tree, and they all had to come down after Christmas this year, and she was looking down at the floor saying “yes, I know, yes, yes, I will” like a chided young child, and then looked up to see one of her PhD supervisors staring at us).

The flat looked ridiculous. Our old friends thought it was hilarious; new friends would come in and stop and stare with their mouths hanging open.

“Um… you lot know it’s June, right?”

“Yeah… [friend] won’t let us take them down”

We moved out in early 2002, when I emigrated to Canada. My friend cried as she finally took all the decorations down. She got to keep them all – but she claims to only display one tree at a time these days.

I don’t necessarily believe her.

But that’s OK. Because now, whenever I see more than one Christmas tree in one place, or any Christmas trees or decorations at all in the middle of summer, I instantly think back to the happy days in our tiny little flat, with good friends and good times.

And that’s the reason for the season.

…………………….

*they came to every subsequent party, too – whoever thought it was a good idea to put student flats in the middle of a posh part of the West End? Our hoity-toity neighbours called the police at 11:01 pm (when the noise by-laws kick in) every single time there was any noise at all. The police agreed with us that this was ridiculous.

Posted in drunkenness, photos, silliness | 16 Comments

“Oncogenesis; Her Majesty The Queen, His Holiness Pope Benedict XVI and The Ferromagnetic Theory of Cancer”

Let me guess – the phrase “WTF?!” has crossed your mind recently. Very recently. Like, since you read the title of this post.

I thought the same thing when I first read that unlikely combination of words, which arrived in my inbox as an email subject heading. I’ve had some unusual emails since I listed myself as the contact person for our department’s website, including a request to add a link to some tuna recipes to one of our research project pages, but this was definitely the most bizarre missive to date.

The body of the email consisted of a URL, and nothing else.  As promised by the title, the link led me into the world of the “ferromagnetic theory of cancer”, aka Iron Conception:

Cancer and ALS/MND are intracellular nano-crystalline ferromagnetic infections. AIDS (infection) cannot endure antiiron slow blood loss.

Apparently,

The Holy Writ and schoolbooks contain this theory. The Holy Writ recommends antiiron healthy diet (raw goat’s milk and meat without blood) and suppression of infections by means of antiiron sulfur (sulphur).

(Oh, and also

The God creates nice women

but I’m not sure what that has to do with iron. But you should check out this photo, from the same site. It’s most illuminating. Oh, and it’s safe for work. It’s not that kind of website).

Why was this link sent to an academic cancer research department?

Well:

His Holiness Pope Benedict XVI can open the Holy Writ and read the ferromagnetic theory of cancer; can help numerous cancer researchers to beat cancer and scientific error by means of the Biblical antiiron anticancer antimoney methods.

and/or

Her Majesty The Queen, Patron of Cancer Research UK can send English schoolbooks ‘Physics’ to Paterson Institute for Cancer Research and Harold Varmus, M.D., co-recipient of a Nobel Prize for studies of the genetic basis of cancer. Great cancer researcher (who cannot understand school ferromagnetic theory-2006 of cancer) was nominated by President Obama as Director of the National Cancer Institute.

and then:

Together we will beat cancer, ALS, AIDS and great money by means of the Biblical accurate non-complicated antiiron methods.

Facepalm AND head-desk! That’s what we’ve been doing wrong all these years! Not involving the Pope and the Queen! D’oh!

There’s lots of other insight in the comments (not), and in the site’s other posts. This page in particular sheds some light on how the ferromagnetic “theory” may have arisen.

This was an unusually quote-heavy post for me. Oh well, one more can’t hurt:

To wear the mantle of Galileo, it is not enough to be persecuted: you must also be right – Robert Park.

Posted in pseudoscience | 20 Comments

Hockey Pool, Week 10

Yay Chall!

Most of us chugged along as usual… with the exception of Chall, who reclaimed top spot with a sterling 34 point week, and Ricardipus, who managed the best weekly total – 35 points – and climbed from 7th place to joint 5th!

I’ve tweaked my team again, but am keeping the same goalie in an attempt to use my rotten goalie-luck to jinx Chicago, the bastards.

Posted in hockey pool | 15 Comments

I don’t talk like this at all, eh?

Damnit, I can’t get the video to embed, despite following Richard’s instructions.

Here’s the link to YouTube

(and another one, because the first one got taken down)

Posted in Canada, English language, silliness, videos | 18 Comments

Second Annual VWXYNot? Readers’ Choice Comment of the Year Award!

It’s the most wonderful time of the year!

Explanation for new readers: every Friday, more or less, I choose my favourite comments from this blog (and my favourite posts I’ve read on other blogs), and list them in the sidebar under the title Bragging Rights Central. In mid-December I go through the archives, tally the wins (Chall had the most “best comment” wins of 2010, and Occam’s Typewriter’s own Cromercrox had the most “best post” wins), pick my 12 favourite comments of the year, and let my readers vote for the winner.

This is no easy task – I’m lucky enough to have some amazingly funny and insightful commenters, and it’s sometimes hard enough to choose the best comments of the week, let alone the whole year! (In fact this year I cheated a bit and have 13 comments on the final list, because two people independently left very similar comments on the same post. I couldn’t pick one but not the other, and they’re so similar that putting both up to compete against each other in the final vote made no sense).

This year’s 12 choices are below, and you can click through to the original posts to read the comments in context. You may notice a strong sport theme, for which again, any new readers may require an explanation: I live in Vancouver, and had basically the most fun month of my life this year when the Winter Olympics came to town, and I also ran an Olympics pool, a world cup pool, and two NHL hockey pools. Plus sport tends to bring out some of the best comments in general.

But first:

VOTING RULES

  1. Please vote using the poll ONLY (link at the end of this post). Any votes cast in the comments on this post, on Twitter, Facebook, other people’s blogs, or by carrier pigeon WILL NOT COUNT.
  2. Please vote only once each
  3. Please do not vote for your own comment!
  4. Voting closes at midnight (Vancouver time) on December 31st
  5. In the event of a tie, I will choose my favourite of the tied comments (I won’t vote otherwise)
  6. The winner will be formally announced as soon as the NYE hangover clears
  7. Prize: ultimate 2010 bragging rights AND a CAD40 Amazon gift certificate (if the two-almost-identical comments win, the prize will be split equally between the two commenters)

(It should perhaps be noted that Massimo, last year’s winner, decided to forgo his monetary prize if I agreed to buy him some beer when we eventually manage to meet up. So, you know, the winner can negotiate what they deem to be a better prize, if they so wish)

And, without any further ado, listed in alphabetical order by commenter’s name, the candidates are:

  1. Alyssa for “Dream DH is a much bigger jerk than in real life – with the cheating and leaving and what-have-you. Real DH wants to kick Dream DH’s ass.”
    AND Antipodean for “MrsAntipodeans dream me is a right bastard. Some days I wanna give him an uppercut”
  2. Antipodean for “The whole of Canada is now drunk.”
  3. Beth for “I once caused a Canuck playoff loss because of a cursed chocolate bar. I got it during one game and we lost. Then we were losing the next game and it hit me that clearly it was the unfinished chocolate bar’s fault and so I forced myself to devour the remainder of the bar and the Canucks then won the game. Which is scientific proof of my theory of the cursed chocolate bar.”
  4. Bob O’Hara for “I heard that the pro-prorogue counter-rally was canceled because of the Olympics. Some people were unhappy at this, and are arranging an anti-prorogue pro-prorogue rally.”
  5. EcoGeoFemme for “My friend’s husband went along with her to a meeting once. He went to the poster session and pretended he was an ecologist. I guess he had picked up enough from my friend that he was pretty convincing, even though he said he was in a somewhat different subfield from her. For some reason, this irritated me more than it made me laugh.”
  6. Eva for “My dad’s never funny. This past week he sent me five pictures of two cat litter boxes from different angles, and still managed to not make that funny at all.”
  7. Nina for “If Google tells you differently, I do not agree. I could argue the whole night if you wish”.
  8. Professor in Training for “I only recently saw a picture of poutine – it looks like it could very well be my favourite food of all time as it contains all of my favourite ingredients that aren’t Doritos.”
  9. Ricardipus for “Woo. Your Canucks beat the Leafs. I wouldn’t crow too much about that – you, me, and those monkeys I keep seeing in your sidebar could probably beat the Leafs.” (NB the monkey thing refers to my old blog, which has a sidebar widget that rotates between all the photos I’ve ever posted. I used to write a lot of posts about primates).
  10. RPS77 for “A term like “Famous Scottish tree hybridiser” is a good reminder that fame can be relative to a particular field.”
  11. RPS77 for “Just think – until the development of the internet, bathroom graffiti was almost the only way for strangers who never saw each other to exchange random insults.”
  12. ScientistMother for “WHAT!!!!! You have readers that don’t care about winter sports? AND you want them BACK????? Why?”

13 great comments – I’m so glad I don’t have to choose! (Please let there not be a tie…. Please let there not be a tie…)

Vote by the rules, please! Off you go!

Click here to vote (sorry, I couldn’t get it to embed)

Posted in Uncategorized | 32 Comments

Not your average cell signalling talk

Welcome, welcome,
Old friends and new.
I’m happy to be here,
I hope you are too!

(That started off as a normal sentence, but then I noticed that it would (kinda) work as a verse, too! Woohoo, I’m a poet and I didn’t realise it!)

Right, that’s set the tone nicely for this new incarnation of VWXYNot?. And seeing as blogging is all about communication, it seems fitting to kick things off with a post about one of the more entertaining research seminars I’ve ever been to.

——————-

My awesome colleague Cristina recently initiated a monthly department-wide “Work in Progress” seminar, distinct from each lab’s own nitty-gritty-detail-driven lab meetings. The aim of the WIP sessions is to give more of a big-picture overview of each person’s research topic; participants are welcome to practice their chalk-talk skills, try out a presentation that would be suitable for a lay audience, or use any other style of their choosing.

Cristina kicked off the proceedings with a talk on her own work, which focuses on the mechanism of action of an oncogenic fusion protein. However, inspired by a TEDtalk (unfortunately I didn’t think to write down which one), she decided to deviate ever so slightly from the standard acronym-heavy cell signalling seminar.

I’m sure we’ve all sat through several examples of said standard seminar, struggling to remember which acronyms match which proteins, and which proteins act as the ligands, receptors, kinases, and transcription factors in the signalling pathway. Hell, some of us might even be guilty of giving such talks ourselves – which you can get away when presenting to your own lab or other specialised audiences, but not when talking to a department that includes clinicians, statisticians, bioinformaticians, chemists, and radiophysicists as well as molecular biologists.

Well, like I said, this talk was different.

Cristina started off by describing how things work in a normal cell.

Here’s a factory, which makes proteins that promote cell growth and division. Within the locked factory gates (nuclear membrane), the security guard (transcription factor) stands on a big red button (gene promoter) that needs to be held down to keep the factory running.

Holding down the fort

And here are some bathing beauties (kinase receptors) at the beach, lying half in and half out of the ocean (spanning the cell membrane). When they manage to catch a beach ball (ligand), they get so excited that they wriggle their toes in the sand, which attracts the attention of the crab (kinase).

Crabs and balls, oh my!

The security guard’s dog (another kinase) spots the crab moving around, and runs to the waterline to check out the action. The crab, inevitably, nips (phosphorylates) the dog. The poor injured pooch then runs back to the factory, where the security guard runs to the fence to comfort him, which releases the big red button the guard was standing on. The factory therefore shuts down and the cells can’t grow or divide.

Worn out from the exertion of it all, the security guard wanders out of the factory gates (into the cytoplasm) and is eaten by a shark (the proteasome). (I’m not sure what the shark is doing on land, right outside the factory, but I guess sharks just make for cooler visuals than land predators). The nommed security guard then gets ripped off the whiteboard and is ceremoniously destroyed by the presenter’s handy electric coffee grinder.

Cristina threatens delinquent proteins with "the grinder"

The fusion oncoprotein is represented by a somewhat confused person who has the security guard’s top half, but the bathing beauty’s legs. Well, maybe he/she (but let’s just say “he”) is confused, maybe the factory just has a more relaxed dress code than most. He can’t catch beach balls, but he does like to kick his legs around at the water’s edge, and the crab (who is admirably non-discriminatory about alternative lifestyles) is just as attracted to this activity as when the bathing beauties do it. Meanwhile, the hybrid guard’s identical twin has retained his security credentials from the factory, and can therefore continue to control the big red button.

As you can imagine, this situation confuses the local wildlife no end. The crab nips the beach-going security guard, who freaks out; the un-nipped dog wanders off and falls victim to the lurking shark (and coffee grinder) instead; and the hybrid security guard who’s still at the factory can’t see his dog, so he has no reason to get off the big red button, and just stands there. This causes the factory to add extra shifts, make too many growth-promoting proteins, and ultimately cause cancer.

Sexy security and confused wildlife

This was all very entertaining, especially the coffee grinder, and even the molecular biologists in the audience appreciated the way the introduction to this signalling pathway was presented. It was so much easier to follow the rest of the seminar when the speaker could say things like “we’ve found that there are too many crabs at the beach” or “if you add this drug, the sharks now ignore the dogs”, rather than “PROTEIN1” (audience thinks: “is that the first or the second kinase?”) “binds inappropriately to PROTEIN2” (audience: “I think that’s the transcription factor, but then again it might be the receptor”).

I wouldn’t recommend this approach at a specialist conference or at your next job interview seminar, but hey, if you’re going into a high school or a community group or something of that nature, it’s a great approach that can work very well indeed.

Just – as I told Cristina – consider how your images will look from a distance before making all your figures. The bathing beauty on the left of the second photo is in fact wearing a bathing suit, but from the back of the room, my first thought was “nekkid ladies? Now this really is a unique presentation style…”

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(Just a note about commenting, before I sign off on this post. As you can see in our (really rather sensible) community guidelines, “Your first comment will be held for moderation—after that you’re free to comment as you like. This is managed on a per-blog basis in the network. If you put more than two URLs in any comment, your comment will again be held for moderation, even if you’ve already been cleared”. I’ll do my best to approve new users’ comments as soon as I see them, but, hey, I do have a day job, too!)

Posted in career, communication, meta, photos, science, silliness | 22 Comments

Twelve Months of VWXYNot?

As seen everywhere, here are the first sentences of my first post of each month in 2010. Bragging Rights Central, hockey pools, grants, visitors, quizzes, and bears – sounds about right! (But no Winter Olympics posts? That’s hardly representative of the year as a whole!)

January

Congratulations to Massimo for winning the First Annual VWXYNot? Readers’ Choice Comment of the Year Award!

February

Did anyone else see the Canucks-Leafs game on Saturday?!

March

I’m currently (intermittently, half-heartedly) tidying my inbox and desk after the latest round of grant applications. 

April

One of my best friends from the UK should be landing in Vancouver in a couple of minutes, with her lovely hubby and adorable two year old son! 

May

My parents are here!

June

As you may remember from an old post, since I moved to Canada in 2002 I’ve spent much, much more time worrying about bears than actually encountering them.

July

My boss is a very busy man whose trainees sometimes have a hard time getting his attention.

August

I’m back from my trip with more photos than I can reasonably fit into a blog post, so please bear with me while I attempt to cull the collection! 

September

Yes folks, it’s time for another fun quiz from my puzzle-a-day desk calendar!

October

New archive post! 

November

First of all, many thanks to Chall and ScientistMother for hosting the last two updates!

December

Spotted on a whiteboard in a PI’s office, written in massive letters (colours as in original):

Book chapters and reviews are for people with no data – NEVER SAY YES

(actually, this was the entire post). 

Right, now let’s see your versions!

Posted in meta | 7 Comments