The Circle Game

Over the last 6 weeks, 2 of my 6 graduate students have defended their dissertations and graduated–which brings me great joy in that they were each highly sought after and both will be heading to outstanding research labs of their choice to continue their training and careers.

sai + bishuang
My two young newly-minted PhDs and yours truly, recently.

I look with great pride at the achievements of these students. In just 4.5 years in my lab, one student has published 4 first-author papers and been an author on 10 published papers–with another first author paper recently resubmitted. The other has published 6 papers, two of them as first author, and has two more first author papers recently resubmitted to journals. And I will add that their primary papers are well respected and cited in the field–so I am very proud of their accomplishments.

I have been at my current position as a faculty member for exactly 10 years, and these two students are #4 and #5 to come out with PhDs. I have also graduated a Masters student and had 2 post-docs train with me: one of whom moved on to a faculty position last summer, and the second of whom is leaving for a new position at the end of this month. Turnover in a science lab is inevitable–it’s not a vicious cycle, but part of the “Circle Game” (as Joni Mitchell once coined the phrase).

Many mentors bemoan the graduation of a student–indeed, this interface of student-mentor on the issue of graduation–a potential flashpoint if ever there was one–is a major theme in my soon-to-be-published novel, “A Degree of Betrayal” (coming soon!). Mentors seem to have difficulty letting go–after all, it takes 2-3 years until the student has completed her/his coursework and degree requirements and developed both the technical skills and critical thinking necessary to really be an effective researcher. So by the time the student starts to become productive, in many cases it seems that they are already wrapping things up.

But while I do have some mixed feelings–particularly about the uncertainty of proper continuity–this is an essential part of science. It’s even rejuvenating–the need to reinvent oneself and train the next generation. So far, also, it has not been disappointing. Great students graduate, and great students step up and take their place. New approaches, fresh ideas, and, well–I certainly don’t become redundant. That’s all a part of the “Circle Game.”

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AMERICA!

America!

It’s been a busy few weeks—or rather few months. Sister’s and families from Israel and Canada visiting, the adoption of Ginger (AKA Vi), two students who have defended their dissertations and graduated over the past 4 weeks, and a ****load of other work-related issues.

nieces + Ginger
Ginger posing with my Canadian nieces, Teighan (left) and Tori

But the summer seems to be dominated by the arrival of Ginger the Vizsla, our very own affectionate Velcro, who sticks to me like “Super-Glue.” As an aside, when traveling in Edinburgh so 18 or 19 years ago, my spouse’s shoe became separated from her sole—not a good thing on a hiking trip. Being cheapo graduate students, we made the mistake of asking a shop keeper if he had any “Crazy-Glue.” He looked at us as though we were crazy—perhaps from sniffing the stuff—and kept shaking his head at these morons who showed up in his shop. “Crazy-Glue,” he said in that not-so-subtle Scottish lilt, “You mean Super-Glue.” That phrase ‘stuck’ with us for a long time…

Ginger has become a fixture in the family within 2 weeks of adoption. She has learned a ton of commands, and her Hebrew is really quite good. “Shvee” (sit), “Artza” (lie down) and “betten” (tummy) just to name a few. This is a dog who would rather have attention and patting/grooming than food or treats—not that she’d pass up on them altogether. She has found her place in the pack, and grooms me regularly. I could probably go without a shower with the way she makes sure I’m clean…

Ginger-tired
Ginger asleep on my stomach.

Ginger loves to swim!

As it turns out, being a dog in the US is generally a guarantee of the good life. Statistics online show that ~36% of households in the US (more than 1/3) have at least one dog, with about 70,000,000 dogs in the US. That’s a huge number—indeed it’s mind-boggling to me.

I had never noticed before the huge sections of grocery store shelves allocated to pet food and apparatus. Or the tremendous variety of types of dog food. Chicken-flavored, lamb-flavored, venison-flavored and so on. Dozens is an understatement. There are easily over a hundred at the local pet store. No wheat. No gluten. No filler. Protein this and protein that. When I had a dog in Israel, there were 2 types of dog food: Dogli and Bonzo. My dog didn’t like Dogli, which I can’t find on the web—so perhaps they’ve gone bankrupt. Bonzo was liked, and I was abl;e to track down a coupon for Bonzo, so it’s still around. But here in the US, dogs are big business indeed.

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Bonzo: exactly what your dog needs–or so says the ad…

I also had been unaware of how businesses cater to pet owners. It turns out that there are a wide variety of hotels and motels that allow dogs. Some have an extra fee, others don’t. But there are many such places. But the real little anecdote I want to tell is as follows:

All through my habitation in Israel, the US was widely admired for its ingenuity. People would talk about “how things are done in America.” Something of high quality or something well organized was done “the American way” or “using the American system.” Obviously this is idolization. But even today, my sisters-in-law from Israel are still absolutely impressed by the order and organization in US society, and overall how generous people are in their interactions with one another. I do agree with this, especially here in the Midwest.

This morning I scooted out to take my daughter somewhere and then set out on a series of quick errands, including the drugstore, gas station, library and bank—to deposit a check. Ginger loves car rides and will do anything to be with me, so I loaded her in the back of the Prius and off we went. When we arrived at the bank, I decided to forego the drive-thru automated teller and use the drive-thru live teller. For those of you on the other side of the pond who may not be familiar, these ingenious stations allow one to pull up beside a little microphone in the parking lot—not physically attached to the bank—with a little chute that one can send a check or whatever to the teller inside. The chute works by air pressure and takes only a second or two to get to the bank or back to the client. I sent my check with a debit card so the teller would know which account to deposit, and before she sent the debit card back to me, she paused and asked politely: “Is it alright if I send a treat for the dog?”

Sure enough a cute little bone-shaped dog biscuit arrived a few seconds later and Ginger, needless to say, was thrilled. I think that she will be happy to return with me to the bank next time. What can I say? America!

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And I thought scientists were smart…

I don’t get it. Really. I just don’t understand. Early this morning, when the first of the 90-odd emails bounced into my inbox, I looked again with disbelief. Yes. Sorry. It’s OMICS again…

Here it is:

Dear Dr. Caplan,

You have been invited to submit a paper for Journal Of Drug Metabolism & Toxicology.

I would be grateful if you would submit a paper for an upcoming issue on “Molecular Mechanisms of Apoptosis and Signalling Pathways”. 

To submit your article, please go to http://pharma.edmgr.com/. Your User Name is XXX-YYY and your password: XXX-ZZZ. 

Please respond to this invitation by 15 Aug 2013.

If possible, I would appreciate receiving your submission by 29 August, 2013. You may submit your paper online at the above URL.

We plan to publish your paper, along with others that we receive in the Aug 30, 2013 issue of the journal.

Benefits of the special issue
Contributors/authors: On special consideration, processing fee for special issue articles: $919

http://www.editorialmanager.com/pharma/ or [email protected]

I THOUGHT scientists were an elite group–and generally smart. That’s why this just doesn’t make sense.

Let’s start with the fact that I don’t do any work on drug metabolism and toxicology. Never have, and likely never will. I’ve also never published anything on APOPTOSIS. So why the hell would anyone possibly think to invite me to write a paper on the subject? With a deadline 3 weeks away. And with a “SPECIAL” processing fee of only $919. Lovely.

Okay, so I’m not naive. And I also know that I’m not an expert or even well versed scientist in the realm of apoptosis or drug metabolism or toxicology. So that makes this a scam. Pure and simple. A way to try and get money off an unsuspecting scientific mark. But what bothers is is that I’ve written about this OMICS company and their scams at least a year ago. This means that if they are continuing to advertise their scams and search for marks, then it must be working. And if it’s working, then what does that say about some of our scientist colleagues out there in the blogosphere *shudders*.

___________________________________________________________

And a quick update on Ginger! I am completely in love with this dog. Smitten. Separation anxiety. The whole bit. She’s well acclimatized, listens to commands (occasionally obeys, too, when it suits her) and spends a great deal of time grooming me with licks to any exposed part of my body. Preferably face and neck. She whined/cried a little (for me–sleeping in my son’s room) the first night, but in successive nights she has snored her way through with no complaints. What can I say? It’s been too long without a dog!

resting
Symbiosis: I’m a pillow and Ginger keeps me warm.

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Lab meeting III–me and my shadow

At the risk of going overboard on the subject of dogs, I find it necessary to post “Lab Meeting III”—because today is a historic occasion—the adoption of Ginger/AKA/Vi (Vizsla) from an animal shelter. Such a rare event that I did something that I seldom do—I took time off without leaving the city.

Ginger in car
Here is Ginger in the car, relaxed as though this were an everyday event.

We have been through quite a lot in this one exciting day, in which ¾ of the family is celebrating (my kids and I) and ¼ is—well—celebrating with perhaps modestly reduced enthusiasm.

Ginger
In this photo of Ginger, one can see the scar still visible from the recent “lumpectomy” that was done by the shelter veterinarian. Turns out that she had a melanocytoma, or benign form of melanoma, which we learned was quite common on the eyelids of Vizsla pointers.

So what was her first day like? We drove home from the shelter—gave her the run of the house, played fetch in the yard, and went for a 3-mile walk. She learned to sit in 10 minutes, and getting her to lie down took about an hour of effort. The hardest thing is getting her stay calm on the leash—especially when a bunny rabbit whizzed by…

steve-dog

steve-Ginger

But the weirdest thing is her behavior toward me! I read that Vizsla dogs are very affectionate and often called “Velcro,” but she seems to have imprinted on me. Basically, I have a shadow. Despite my kids and everything else, where I go, she goes. Bathroom and all. And when I popped out for an errand for 15 minutes this evening, reports have it that she sat patiently by the door.

Even now, writing these few lines, Ginger is at my feet. Every now and then, she gets up and tries to lick me, and induce some patting and play. I’ve never seen anything quite like this! Velcro is the perfect description. Well, it’s good to know that someone wants me around!

But HELP?! Any dog owners out there with tips on how to reduce “neediness” in a dog? Please?!

NEW TRICK:

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Lab meeting–Part Two

Our second unusual lab meeting took place in the Prius on our way home from Hearts United for Animals (HUA), close to Auburn, Nebraska, a small town about 60 miles south of Omaha.

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HUA is an animal shelter with a huge facility, and they save dogs and cats in Nebraska and from around the US. They have a very large ranch-like facility, in a beautiful rural area staffed with many dedicated workers and volunteers. My understanding is that they pride themselves on saving all animals of all ages–from puppies bred under horrific conditions at “puppy mills” to strays and older dogs that some owners can no longer care for. Very impressive!

This was “the” visit, where my kids and I came to see a specific dog whose current name is Vi. We were looking for a dog with Labrador features, but since we have no particular interest in “purebreds,” we were simply searching for a medium-to-large sized dog with a nice temperament who is friendly with kids. What we found was a mixture of Labrador with a dog with a a similar temperament, from the Pointer family, called a Vizsla.

Initially, Vi was a little shy with us, but within half an hour, she was chasing down balls, and getting tummy rubs. We spent about 2 hours at the HUA, and when we piled back into the Prius, it was all over but the voting. The Lab meeting committee admitted the candidate immediately–what a gorgeously cute and affectionate dog! I was delegated as chair of the training committee, having had previous experience. My kids are co-chairing the naming committee–a committee to which I was not invited to join–possibly due to my quirky sense of humor. In any case, pending a house inspection by the agency, it’s a done deal for early August.

Just as an aside, before I put up a few choice photos, I wish that the backgrounds checks for gun owners in this country were half as thorough as the way HUA checks out families that want to adopt.

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Tennis, anyone? This ball is falling apart.

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Very affectionate! The dog, not me.

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I know when I’ve been licked…

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Photo is a bit fuzzy, but that’s a winning smile!

I’m even planning to take off a few days from work to help her settle in. Big excitement in the family.

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Professor

This 4th of July marks almost 10 years of my life in Omaha, Nebraska, and in addition to celebrating Independence Day, I am also personally celebrating my new title: Professor. Well, sort of. Because it’s not exactly a time for celebration among scientists in the academic community. Researchers are losing their long-term personnel, their labs, and even their jobs. I’ve been extremely fortunate in the midst of this turmoil, but I am making huge efforts to avoid any downsizing of my own lab, and my luck might not hold out indefinitely.

But for now, it’s important to celebrate any victories, and rising to the ultimate academic rank as professor is surely a cause to feel some satisfaction. In my institute, and many others in this country, this is an earned rank that many do not reach. It does not depend on nobility or birthright, as do titles of earls and dukes, and the process of promotion is tightly regulated through a variety of committees, beginning in my own department and on through the medical school. There are 3 general areas in which one must show evidence of high levels of international or national recognition, and these are: Research, Service and Teaching.

For me, oddly enough, this whole issue of academic rank reminds me very much of my service in the military, all those years ago. When as a private I was selected to attend crew commander training course in artillery, it was known that all of the surviving recruits after the 3 months intensive course would be promoted to corporal (2 stripes; skipping private-first-class at one stripe). A handful of the excelling graduates would immediately become sergeants (3 stripes)—which was a big honor, but entirely meaningless from a practical standpoint. I somehow managed to emerge with the 3 stripes (I’ve always been good at meaningless and pointless exercises)—and almost see myself now as having made the sergeant—or in the officer class—captain—rank.

sc-uniform
Me, 30 years ago, eyes wide closed. Probably asleep while standing. Note the 3 stripes indicating a newly-minted sergeant rank

So now having reached my exalted new rank, what new duties and responsibilities await me in the future? I don’t know; like everyone else right now, I’m focused on survival mode. But hey, I may take a day to celebrate.

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Lab Meeting!

I am not given to holding an excess of lab meetings, but by Ezekiel, this one was needed. And no waiting around for a reasonable time, like 10 a.m. No, no, that wouldn’t do. So I called a lab meeting at 10:30 p.m. Location? Where it’s most comfortable–my bed.

Okay–hold on. Reading this, you must think there is something quirky going on with this Caplan guy, right? Wrong. There’s a simple and rational explanation. Read on, yes, read on…

Taking part in the lab meeting were my two kids–both extremely excited to be a part of the process. What process? Well, talking about getting a lab: a Labrador Retriever, that is!

This whole “Lab Meeting” has been years in the making. About 13, to be exact. That’s about the time since we last had a dog, and only one of our kids was born. The dog’s name was Rodrigo (we adopted him with the name), and he was an unbelievably clever, cute, but stubborn, jealous-to-the-point of paranoid dog. People would ask me “What breed?” My standard answer was 50% terrrier, 50% mule. Probably true.

Rodrigo
Rodrigo and me. Not-so-recently.

Rodrigo had a bad habit of snapping at people. Unlike many dogs, there was no problem handling him when he was eating or drinking–his problem was that he didn’t like to be disturbed when resting. If he came to someone for attention, petting, massages or play–wonderful. But if you initiated contact with him–ouch!

For many years after Rodrigo’s passing, we tried other pets. Fish, guinea pigs. It’s just not the same.But life is complicated with tough schedules, work, travel–and the fear that adding a dog to the family would end up being one more chore for two over-worked parents. But a long campaign from the juniors finally yielded a change of heart. I was on the fence anyway, as I typically enjoy the company of dogs more than most humans, but my wife was a hard sell. But the die has been cast, and when our troupes of summer visitor finally fly and drive away, we will be searching for a relatively young house-trained yellow Labrador Retriever to adopt. There are a number of great agencies, including the Midwest Animal Rescue and Services, Labrador retriever Rescue and Adoption, Hearts United for Animals, and of course the Nebraska Humane Society.

While “Hobson” came out as a cute dog:
hobson

I am definitely bent on a more Labrador-like-look, such as Vi, here:
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But as I haven’t had a dog for a companion in many years, I’m definitely open to expert advice and guidance, and getting up to speed on new technologies in training and caring for a dog. All suggestions/comments appreciated!

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Perennial publicity hound

Well here it is. I have finally managed the ultimate in publicity stunts: wangling an interview/feature story with the American Society for Biochemistry and Molecular Biology (ASBMB). Beware of TMI–for those of you who are not so savvy with the texting lingo, that’s “Too Much Information.”

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Peggy Wheelock-the ultimate in research and mentorship

This blog has been long in the making. Long, because until recently, I’m not sure I would have been able to type out these words without flooding my keyboard with tears. But the time has come for me to write down a few personal thoughts about Peggy Wheelock.

This week, about four and a half years after Peggy’s untimely death, we had the first annual Peggy Wheelock Award for Excellence in Research, Mentoring and Promotion of Women in Science–awarded to Dr. Jean Schwarzbauer of Princeton University. Dr. Schwarzbauer is, of course, a perfect recipient for this award, but for this blog I am going to focus on Peggy.

Peggy and her scientific and lifetime partner, Dr. Keith Johnson, were recruited to the University of Nebraska Medical Center (UNMC) in 2001 from Toledo, Ohio. Peggy had a distinguished career as an outstanding cell biologist with a stellar and international reputation. But no less than her research was her passion and capacity for mentoring the next generation of scientists. Within a year of arriving in Omaha, she had already initiated the Nebraska Center for Cellular Signaling (NCCS)–a program devoted to collaborative efforts in our somewhat isolated state, and especially to the development and mentoring of young faculty members.

Peggy successfully received one of the largest federal grants in the history of the state to do this, and put together a group of devoted mentors to help out young faculty members who were accepted into the program based on merit. Under Peggy’s able leadership, and with Keith as her second-in-command, this NCCS program at UNMC became one of the most successful ever–a program to be emulated.

I had the good fortune of meeting Peggy in 2003, shortly after joining UNMC. In my interviews and subsequent visits to UNMC, each time she had been out of town, and I had been told by dozens of people about her. If I had met her on one of my interviews, it would likely have made my decision even easier to join UNMC.

Asked to join the NCCS program as a young project leader, I found Peggy to be one of the most remarkable people that I had ever met. Brilliant, but without pretenses, entirely direct and comfortable in her own skin, she was the penultimate leader and one of those people who just knew how to get things done. Now I am someone who prides myself on my own independence–not the sort of person who typically follows others–but if Peggy had asked me to jump off a cliff, I probably would have done it without thinking twice.

Over the years, as I advanced through the system, I also became a mentor for junior scientists in our NCCS program–in fact, I was first asked to help out when Peggy became ill about 5 years ago. While her shoes will always be too big for anyone to fill, the overwhelming unity and desire to pitch in by the people who knew Peggy exemplifies her impact on us all.

The following anecdote serves as a brief example of the type of person that Peggy was: one day, I was sitting in my office, working on on a grant and the phone rang. It was Peggy. She said, “Steve, I’ve been thinking about your career, and I think it’s time for you to get your name on some journal editorial boards.” Now, what’s remarkable about that statement is not simply that it was true–and Peggy very astutely pointed that out. What’s mind-boggling is that I realized that there was someone else out there in this universe who actually gave a damn about my career development! Those of us in science know that it’s a lonely world-sometimes a dog-eat-dog world, with everyone busy and struggling with their own agendas and careers. The idea that Peggy was taking time to consider my career was something that to this day I have trouble fathoming. And rather than merely alert me to the idea of joining editorial boards (which I have since done, and perhaps serve on too many, now), Peggy’s phone call and style of mentorship has had a lasting impact on me and has taught me a lot about the way I want to be remembered one day by other scientists.

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The week in review

I just returned home from a 2 h walk, using my new pedometer app on the iPhone: in all 1:55 minutes with an average pace of 4.7 mph and a total of about 8.7 miles. What I forgot to do was to bring a bottle of water, and I found myself slightly dehydrated as I downed 2.5 L of water upon returning home. I did see a bright orange Baltimore Oriole, but could only manage to get a photo of this guy:

Rabbit on trail

Somewhat exhausted, I now have the prospect of spending the Memorial Day long weekend dealing with this:

work for the weekend

These happen to be initial drafts of Ph.D. dissertations from two of my senior students, who plan to graduate in July.

It’s not as if I haven’t had a week full of reading–although not every week is quite like this, I submitted 2 papers this week, one to PLoS ONE (first time, despite being an editor for the past 3 years!) and a second one to the Journal of Biological Chemistry (where I also serve as an editorial board indentured slave member. And a resubmission/revision of a review.

Indeed, it has been a busy week, including the graduation of my son from elementary school, and my daughter’s performances in “Recommended Reading for Girls” at the Omaha Community Playhouse Theater. My claim to fame is Caplan’s Cabbies, where I serve as owner, director, and #1 driver.

It was also a busy week as I have been easing back a tad on the blogs and forging ahead with major revisions on my novel suggested demanded by my editor. I am very excited at straying a little into the realm of mystery–with the death of an academic researcher in my novel. My novel also takes place in the city of Omaha, Nebraska, where I have lived these past–holy shite–10 years! I thought it might be fun to use the streets and landmarks that are familiar to me–and of course, when push comes to shove, the marketing of the book locally might be a plus. We shall see if the editor appreciates my two months of work. She also asked for a new title: so the tentative title of “Let My People Go!” has been modified to: “Let My Student Go!” Yes, it’s about a student whose mentor gives her grief about graduating. Sound familiar to anyone?

Well, as much as I’d love to blog on, there are a couple of stacks of reading material awaiting me…

 

 

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