Winter cometh

Winter cometh to our lilac bush, recently

The problem with being a scientist, and a cell biologist as such, is that everything reminds me of cellular organelles. These icicles remind me of the membrane bound tubules involved in endocytic recycling…

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…And so say all of us…and so say all…

My belated congrats–couldn’t resist joining in, although I was a latecomer. So a quick ramble:

One day, I was minding my gap, when someone came up to me and said, “I have a confessionI was driving by the city limits and stopped to watch the end of the pier show and read athene donald’s blog.” “Were you trading knowledge?” I asked, “and if not vwxynot?“”No, I found my reciprocal space at science behind the scenes.””Were you blogging the PhD, or were you—-” “No!” the girl interrupting me,I’m not ranting!”

No comment,” I said.

 

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It’s that time of year

Nearly every year I try to make my way to the American Society for Cell Biology meeting. This year, it’s surprisingly close to home, being held in Denver, Colorado. Recent years have seen it traditionally in San Francisco, San Diego and Washington, DC, with Philly last year being an exception as well.

For me the meetings have evolved tremendously from when I was a student and post-doc. I am less stressed about being able to run around from talk to talk and poster to poster. Indeed, I feel much more comfortable at these meetings, as I find that I suddenly know a lot of people, and surprisingly, a lot of people seem to know me. In fact, even getting from poster to poster is often difficult, with the necessity for social intercourse with anyone who recognizes me on route through the enormous hall.

Another difference for me is that I rarely come alone anymore. In fact this year, including myself, my lab is a contingent of 8 people. My own cheering section at the seminar I’ll deliver tomorrow afternoon. This also leaves me with a responsibility to make sure everyone is okay, behaving, and is meeting other scientists and not going out for dinner alone or only with people from the lab. Me, the social coordinator. Not really in my job description, says the anti-social PI…

One other thing that has evolved over the years is the advertising. Companies and vendors are becoming increasingly aggressive in their marketing. Perhaps I should take a lesson from them in peddling “Welcome Home, Sir.” Prior to the meeting, huge amounts of postcards were arriving in my mailbox–“visit this booth and that booth,” “enter a draw for an Ipad,” and so on and so forth.

Well this year, something even newer: for example, have a look at the back and front of this new card key at the Hilton Hotel:

 

Back of the card key to enter my room

Front of the card key to enter my room, recently

The only problem–the key wouldn’t work, and finally they had to replace it (after being locked out of my room for 15 min) with a “regular card key.” Doesn’t give me very good vibes about purchasing Xtreme gene…

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BOOK LAUNCH!

It’s finally here, the “Book Launch” for my new novel, “Welcome Home, Sir,” published by Anaphora Literary Press!

After the 13 year struggle for publishing “Matter Over Mind,” this time I seem to have done it with the speed of light. Relativity speaking. Sorry–not the time for bad puns…

Happy as a pig in sh*t

An interesting similarity between scientists and authors is that publication–be it papers or novels–always seems to be an anti-climax. After struggling to overcome reviewers’ comments, or editors concerns, the manuscript/novel is finally accepted and put “in press.”

But then, by the time the actual work is published, the scientist/author is never standing still and waiting to celebrate. No–time doesn’t stand still, and the projects and new novels move on. We are never satisfied with what we have. Although I never understood the materialist types who yearn for more and more money, I guess this is the equivalent–the never ending desire to create, learn and–well yes–to impress our peers.

But I will take a break–at least for a day–and try to smell the flowers (dead trees?) and celebrate symbolically.

For any of you out there interested in fiction portraying a real-life scientist suffering from post traumatic stress disorder, weaving around some intriguing issues within his own laboratory–this may be for you. Support a poor struggling artist (emphasis on struggling…).

Here are some links:

My Amazon author site: (note the Amazon “look inside” feature)

At Anaphora Literary Press:

My own website–where you can also grab a copy of “Matter Over Mind:”

And oh–in case you like it–please put up a sentence or two on Amazon as a reviewer. It’s amazing how much that seems to make a difference.

 

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Playin’ Possum? Impossumble…

An opossum, recently

For some time now, I have been treading carefully when mowing the lawn (which is now no longer necessary despite our mild weather this year) and raking the leaves. The reason for this is that a mysterious creature had been leaving rather smelly bundles of scat scattered (love that alliteration!) throughout the yard.

The mysterious creature has been identified, as I was suddenly jolted from the comfort of the smallest room in the house to see our visitor sitting on the fence. Not politically speaking, of course.

Well, this being America, it did not take long before my spouse Dr. N. heard the sound of something colliding with the back wall of our house. And then again. Rushing to the upstairs window with the greatest vantage point, we watched in horror as the neighbor from across the way aimed a rifle at the opossum. The sounds we had heard were probably pellets from the air rifle hitting the wall of our house.

Well, I realize that for some these critters may do damage to the garden/yard/property, but sometimes the hunter-gatherer instincts are too much. With some loud shouting the rifle bearing neighbor reluctantly put down his weapon. Dr. thought she may have seen some blood on our furry friend, but we are hoping he/she got away.

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Where the hell is regulation when it’s actually needed?!

Anyone with any relationship to science will tell you horror stories about bureaucracy and regulatory issues hindering science. One classic example of how ridiculously out-of-touch bureaucrats have become was described here by Jenny Rohn fairly recently, with rules mandating that scientists need to wear safety glasses at all times.

Now despite the clownish idea, one must remember that these regulations–at least in theory–are in place to protect people. Of course, one might argue about which people–whether they are actually the researchers, or the policy makers (who want to be protected against potential law suits).

However, cynicism aside, the rules are supposed to be to protect people.

Needless to say I was absolutely shocked when a close friend of mine living on the other side of two ponds in a small country in the middle east told me the following story:

My friend underwent thyroid ablation years ago following the discovery of a growth, and as a consequence became reliant upon thyroid hormones to replace those no longer being generated in the body. It took some time, but after awhile the hormone levels were properly balanced and life became bearable.

Over the past 6-8 months or so, my friend has had a variety of health issues–not being one to complain about minor aches and pains, I knew these were not the type of hypochondriac-based concerns typically held by yours truly. There were 3 visits to the emergency room, serious joint pains and inflammation, and a variety of other issues. In short, no fun at all. But the most worrisome issue was that no one had any idea what was the cause of any of these symptoms.

Cutting to the chase–serendipitously, my friend found out via the the interwebz that the formulation of the thyroid replacement hormone (called Eltroxin) made by GlaxoSmithKline was ‘reformulated’ so that the active agent was kept the same, but apparently non-active stabilizing chemicals were altered. Here is a report on the web that seems to summarize what I have been reading:

I’ve just read in the Israeli press that since February 2011, a new formulation of Extroxin has been made available, and since then my thyroid has been completely out of balance causing me to be very sick with terrible brain fog, insomnia, loosing weight, problems breast-feeding and my hair falling out.

Previously the only brand available was produced by GSK. A new formulation made by Aspen (Perrigo in Israel) was introduced in February and is now being given to patients interchangeably with the GSK brand. There are also some other differences in the ingredients listed here:

http://alerts.adr.org.il/eltroxin_formulation
The manufacturers claim that the active ingredient levothyroxine is the same, but just the inactive ingredients have been changed to make it more stable.

The packaging is almost identical and apparently doctors were notified of the change at the end of March, although my doctor never mentioned this to me. Apparently now after thousands of complaints and many people falling sick, the manufacturer is placing a warning sticker on the new boxes to say that the formulation has changed and that patients must be monitored closely.

I can see that something similar also happened in New Zealand a few years ago.

My thyroid has been totally out of balance since collecting the new pills in February (my TSH reaching a high of 132 at the end of February). I have been taking between 150-200 mg a day since then but my TSH seem to fluctuate wildly from 9 in May to 0.11 in September. My 100mg pills are GSK and my 50mg pills are Aspen.

Before this I was balanced for the previous two years taking 100mg a day, including all the way through my pregnancy last year. I have been diagnosed with hashimoto’s thyroiditis.

It seems to me that my problems could have been caused by the new formulation, although until now I assumed it was some kind of post-pregnancy thyroiditis.

Can anyone shed light on the differences in these two formulations, and whether/how/why they could be causing my thyroid problems?

Now this may be relatively new in Israel, but the formulation of this medication changed back in 2007 for those living in New Zealand (and the issue is well explained in this blog entitled: Betty Dong Redux (from Boots to GlaxoSmithKline)), and as one can see from the following comment online, 3-4 years ago the very same symptoms my friend was suffering from were already reported in NZ:

Continue reading

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Rational goals for science education

There were two events that conspired this past week to lead me to the topic of education–and particularly science education. The first was the unlikely event in which I actually watched television. Although we do have a small screen telly at home, it is rarely used. The US Public Broadcasting Station hosts a favorite from back in my childhood on Sunday evenings–Masterpiece Theatre, which includes a lot of great British BBC drama (from Henry’s much revered Downton Abbey–apparently airing new episodes come January, to Jane Austen’s Pride and Prejudice and so much more).

Well all that, for the rather long-winded way of saying that this is pretty much it for any watching television, and even then it’s usually at a more convenient time on the computer. So it was rather coincidental that I happened upon Farid Zakaria’s program GPS on CNN. The topic was education in the US–specifically in the STEM arena, with an interesting comparison to education in two other countries: S. Korea and Finland. I’ll come back to that in a moment.

The second event was my guest appearance as a scientist to promote the idea of science-as-a-career at my son’s elementary school (5th and 6th grades). Despite the fact that my kids like to portray me as a tough old codger who scares children, I know hope they don’t really believe that. After all, for years they always requested me to handle the entertainment and fun-and-games side of their home-made birthday parties. So I must have some ability to talk to children.

Some insight from these two coincidental events: Zakaria portrayed an extremely hard to picture situation in Korea, with students learning 18 hours a day in the maths and sciences in order to get ahead and hopefully gain acceptance to university. In fact, remarkably, he explained that a whole slew of evening preparation courses to advance in math and science have opened in Korea and that there is a terrible problem: the youth stay at these learning centers and study until midnight. The problems with this system were becoming so severe that the government actually passed a law making it illegal to have these tutoring centers open after 10 p.m. In order to enforce this law, crews were hired to go around the city and report any illicit studying after the 10 p.m. deadline.

So while western cities have tremendous gang, drug, alcohol and prostitution issues at night, Seoul has the huge problem of overly motivated high school students who just want to keep studying and refuse to get a good night’s sleep.

Zakaria then moved on to the situation in Finland–the idea being that both S. Korea and Finland are at the very top of countries with regards to education in math and the sciences (at least based on a wide variety of standard tests). In Finland, however, the situation is very different. The youth in Finland do not have more contact hours in school, or a tendency to go to tutoring schools after regular school hours. In Finland, apparently, the education system is a success due to outstanding teachers. These teachers–even for elementary school–need a Masters degree. And getting into teaching in university is hugely competitive, with only the top 20% being accepted. Teachers are treated like royalty–being a teacher is akin to being a university professor or medical doctor, as far as status, and teachers are very well paid.

In comparison, while teachers can certainly earn a decent living in the US, Zakaria noted that the average lawyer’s starting salary is $116,000 more than the average teacher’s starting salary in the US. I don’t even want to compare to the average college football coach (we’ve had that discussion before…).

The teachers in Finland, apparently, do not spend any formal time preparing students for standard exams; in fact the teachers–being the brightest of the bright–are given free latitude to teach however they like. And they seem to do an excellent job instilling concepts and promoting creative thinking, rather than simply expecting students to cram material and memorize, or simply technically cram algebra and calculus.

When I visited my son’s school this week, his teacher–who is an outstanding teacher–asked me to talk a little about the scientific method, and what a career is like as a scientist. To discuss the scientific method, I adapted some slides that I found on the interwebz to suit my own purposes, and talked about the example of baking a loaf of bread, and testing the hypothesis that the more sugar added, the more the bread would rise.

It was a great opportunity to take the students through all the considerations of controls, dependent and independent variables, and look at data and interpret them, and revise our hypothesis. The children were terrific–as I had anticipated–and we had great discussions and even talked about separating cause and effect. One could clearly see the training in scientific reasoning that they had acquired from the teacher.

Superb questions were asked, and even later, when I discussed science as a career, one child asked whether scientists have messy benches. Fortunately I could take them to an earlier blog of mine here on OT showing 2 opposing styles of researchers in my lab (both productive!). They liked that!

Finally, I also had the opportunity to show them Stephen Curry’s trailer from “I’m a  Scientist.” That was also a big hit!

Putting everything in perspective, I have come to the albeit anecdotal conclusion that science and scientific thinking probably doesn’t differ much from learning a language or learning to play a musical instrument. Starting young, rational or skeptical thinking can easily be developed–and that’s the most important and critical element for a scientist. All of the other information overload can be obtained later.

It’s the thought that counts.

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Transferance in performance jitters

Being in science since 1986–which would mean about a quarter of a century since I began to study in university–I have spent a lot of time learning to communicate, both in writing and orally.

I’m not sure when I lost my jitters and nervousness at standing up in front of crowds of people and speaking, whether it occurred gradually over time, or whether there was a defining moment where I said to myself “This is not so frightening.” I do know that it’s been a long time since I had such stage fright–with the exception of my first book reading last year–which was an entirely new experience.

Yesterday evening I had the opportunity to listen to a music recital, in which my daughter participated, and I had a startling revelation. I just hadn’t really noticed or connected the dots. Every time one of my children performs (and it doesn’t matter what)–in school or community playhouse plays and musicals, in Taikwando testing–you name it and I’m suffering the jitters.

For those of you who have children, I’m curious as to whether you undergo the same stress?

But my startling revelation was that every time one of my students or postdocs presents her/his science in a forum outside the confines of our lab–I’m also sh*tting bricks, pardon the expression. Is this natural? Can anyone help me out? And will these jitters dissipate over time, or am I resolved to a life of endless new stressers as students and post-docs come and go from the lab?

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Truth Serum

Scientists have been given a bad reputation by being inherently literal. But there is a limit to the amount of bullsh*t that I am willing to hear without fighting back.

I can recall having endless dead-ended conversations about “carbs” this and “carbs” that. For those of you who may actually have been fortunate enough to avoid hearing such discussions, the reference is to carbohydrate calories taken in from food. The fact of the matter is that people use these terms loosely, and wouldn’t know a carbon from a xenon if it flashed in their face and the valence electrons did a little ditty. With such lack of basic understanding, no wonder people are superb prey for all the homeopathic propaganda.

The other day I had a nice leisurely walk around my favorite nearby lake, and came home to have a nice hot shower. In the course of my shower I noticed the following hair conditioner product on a shelf (not mine, I don’t have enough hair to merit such a thing):

Truth serum, recently.

What the hell ISrepairing serum?”

As a scientist who takes things literally, serum is serum. Ain’t that the truth, serum. The dictionary has the following definitions, all related to blood serum:

Noun

serum (plural serums or sera)

  1. The clear yellowish fluid obtained upon separating whole blood into its solid and liquid components after it has been allowed to clot. Also called blood serum.
  2. Blood serum from the tissues of immunized animals, containing antibodies and used to transfer immunity to another individual, called antiserum.
  3. A watery fluid from animal tissue, especially one that moistens the surface of serous membranes or that is exuded by such membranes when they become inflamed, such as in edema or a blister.
  4. The watery portion of certain animal fluids, as blood, milk, etc; whey.

Wonderful Wikipedia actually does make a brief mention of “Cosmetic Serum, describing it as: “Cosmetic serum, a cosmetic product that is more expensive than a cream.”

Great! What a definition! Humor me!

It’s time to hold the hair product company (Dove) accountable for their “serum.”

I wanted to contact the company and simply ask, “Why do you call this serum?” At least give them a chance to respond. The Dove company internet site had a “contact” section, but this was a dead end. One could ask a question, but given that there was no place to plug in e-mail (see screen shot below), I saw this as another fictitious enterprise:

I tried their to send them a Tweet question, but their setup for Twitter was fixed in a way that one could not Tweet a question to them. And so it goes. ENOUGH!

I would recommend they be forced to swallow their own Truth Serum–sounds like the only way we’d get any real answers.

 

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Reading honeymoon

Having recently reported that my second and new lablit novel, “Welcome Home, Sir” will be coming out in the near future, and now in the process of deciding between two disparate options for the plot and characters of novel #3, I find myself with–well–a bit of extra time in the late evenings. Something I am not really used to, although for a time it can be advantageous.

I’ve seen a few films on my laptop, done a little extra science reading, but mostly I’ve had a chance to increase my reading output. Or should that be input?

This past week was a rarity for me, having managed to 3 read outstanding books–but that’s not what was unusual. The rarity was that 2 of the books were non-fiction, which I generally shy away from. The first non-fiction book was called “Jacob’s Ladder,” written by one Henry Gee, a well known paleontologist and celebrity nutritionist with a wry sense of humor and a talent for putting things nicely into perspective. As a fellow scientist, I was not bored by already understanding most of the things written, and I believe that a layman with any curiosity would easily understand and enjoy the book. The book sells for a steal–hardcover for only $8 (don’t be tempted to buy a used one for 1 cent, it’s not fair to the author).

I will come to the other non-fiction book in a moment, but first I’ll mention the wonderful fiction that I read this week–a bona fide book from Jenny’s lablit list (and I initially thought I had discovered an “unknown” lablit book) called “Mendel’s Dwarf” by Simon Mawer. For those of you who enjoy science biographies as well as fiction, this one really has the best of both worlds, with a very illuminating (yet fictional) depiction of Mendel and his life, nicely interwoven with a modern day lablit story–all told from the (ground level) vantage point of an achondroplastic dwarf who is a genetic researcher. Ironic–yes. But also timely. After all, Nobel prize laureate Ralph Steinman worked against the clock to use cancer vaccines based on his own discoveries of dendritic cells as antigen presenting cells to try to stave off his own pancreatic cancer. Potentially with some success.

In any case, “Mendel’s Dwarf” is highly recommended by yours truly.

My second non-fiction title last week was another work by the inimitable Bill Bryson. I was already familiar with Bryson, having read, and then listened to an audiobook (with about 20 CDs) of his brilliant “A Short History of Nearly Everything“–so that my wife, who prefers books in her native tongue–could hear this masterpiece on a long car trip a few years back.

Bryson describes brilliantly and with great humor in “A Walk in the Woods” his attempt to walk large parts of the famous Appalachian Trail. In particular are hilarious bits about the quirky people he met along the trail and at resting spots along the way. I could definitely relate to Bryson’s comment about his feeling that the stupidest people seemed to be attracted to him. One especially irritating person was “Mary Ellen,” who attached herself to Bryson and his friend (and they were forced to ‘ditch her’–the option was either that or to kill her, as he noted). A voracious talker, and one who would stop only to clear her Eustachian tubes by plugging her nose and making obnoxious geese-like noises, nearly caused me to fall off my bed laughing.

Without giving too much away, there was one part where Bryson’s witty and cynical friend asked her if she wasn’t worried that her eyeballs might fall out when doing that, and then proceeded to tell her about a friend who used to do that until his eyeball fell out, rolled across the floor and the dog scooped it up and swallowed it before he could do anything. Poor Mary Ellen wanted to know what the man did–did he get a glass eye? No alas, they were a poor family, so they used a ping-pong ball with an eye drawn on it….

My own eyeballs nearly popped out from laughing so hard.

Seriously, though–for anyone who has spent time outdoors on a trail–eating cooked noodles night after night, finishing a trail and coming to a town bone-tired and half starved–showering and feeling the lack of excess flesh when soaping oneself–this book is for you.

Alas, my book honeymoon is soon over, as it’s time to return to writing. Back to the Appalachian Trail of writing fiction–as soon as I can make a decision on which novel comes first.

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